3-(2-chloro-4-ethynyl-6-methoxyphenyl)-2-methoxybicyclo[3.2.1]oct-2-en-4-one

Base Information

Chemical Name:3-(2-chloro-4-ethynyl-6-methoxyphenyl)-2-methoxybicyclo[3.2.1]oct-2-en-4-one
CAS No.:1615212-11-7
Molecular Formula:C₁₈H₁₇ClO₃
Molecular Weight:316.784
Hs Code.:

Synonyms:3-(2-chloro-4-ethynyl-6-methoxyphenyl)-2-methoxybicyclo[3.2.1]oct-2-en-4-one

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Chemical Property of 3-(2-chloro-4-ethynyl-6-methoxyphenyl)-2-methoxybicyclo[3.2.1]oct-2-en-4-one

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Technology Process of 3-(2-chloro-4-ethynyl-6-methoxyphenyl)-2-methoxybicyclo[3.2.1]oct-2-en-4-one

There total 10 articles about 3-(2-chloro-4-ethynyl-6-methoxyphenyl)-2-methoxybicyclo[3.2.1]oct-2-en-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1615202-04-4
3-(2-chloro-4-ethynyl-6-methoxyphenyl)bicyclo[3.2.1]octane-2,4-dione

: 74-88-4
methyl iodide

: 1615212-11-7
3-(2-chloro-4-ethynyl-6-methoxyphenyl)-2-methoxybicyclo[3.2.1]oct-2-en-4-one

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 16h;

Reference yield:

: 1615212-15-1
3-[2-chloro-6-methoxy-4-(2-trimethylsilylethynyl)phenyl]bicyclo[3.2.1 ]octane-2,4-dione

: 1615212-11-7
3-(2-chloro-4-ethynyl-6-methoxyphenyl)-2-methoxybicyclo[3.2.1]oct-2-en-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 2 h

2: potassium carbonate / acetone / 16 h / 20 °C

With potassium carbonate; In methanol; acetone;

Reference yield:

: 497-38-1
Norbornan-2-on

: 1615212-11-7
3-(2-chloro-4-ethynyl-6-methoxyphenyl)-2-methoxybicyclo[3.2.1]oct-2-en-4-one

Guidance literature:: Multi-step reaction with 9 steps

1: potassium hydroxide / ethanol / 19 h / 85 °C / Inert atmosphere

2: dihydrogen peroxide; selenium(IV) oxide / water; tert-butyl alcohol / 48 h / 20 °C

3: eatons reagent / toluene / 1 h / 70 °C / Inert atmosphere

4: potassium carbonate / acetone / 22 h / 20 °C

5: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine / tert-butyl methyl ether / 4 h / 80 °C / Inert atmosphere

6: copper(ll) bromide / methanol; water / 1 h / 80 °C / Inert atmosphere

7: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 3 h / Reflux

8: potassium carbonate / methanol / 2 h

9: potassium carbonate / acetone / 16 h / 20 °C

With selenium(IV) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; eatons reagent; dihydrogen peroxide; potassium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; potassium hydroxide; copper(ll) bromide; In methanol; ethanol; tert-butyl methyl ether; water; acetone; toluene; tert-butyl alcohol;