tert-butyl (3aR)-1,1-dioxotetrahydro-1H-1λ⁶-[1,2,3]oxathiazolo[3,4-a]pyrazine-5(3H)-carboxylate

Base Information

• Chemical Name: tert-butyl (3aR)-1,1-dioxotetrahydro-1H-1λ⁶-[1,2,3]oxathiazolo[3,4-a]pyrazine-5(3H)-carboxylate
• CAS No.: 1450620-52-6
• Molecular Formula: C₁₀H₁₈N₂O₅S
• Molecular Weight: 278.329

Synonyms:tert-butyl (3aR)-1,1-dioxotetrahydro-1H-1λ⁶-[1,2,3]oxathiazolo[3,4-a]pyrazine-5(3H)-carboxylate

Chemical Property of tert-butyl (3aR)-1,1-dioxotetrahydro-1H-1λ⁶-[1,2,3]oxathiazolo[3,4-a]pyrazine-5(3H)-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (3aR)-1,1-dioxotetrahydro-1H-1λ⁶-[1,2,3]oxathiazolo[3,4-a]pyrazine-5(3H)-carboxylate

There total 1 articles about tert-butyl (3aR)-1,1-dioxotetrahydro-1H-1λ⁶-[1,2,3]oxathiazolo[3,4-a]pyrazine-5(3H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate (278788-66-2) → tert-butyl (3aR)-1,1-dioxotetrahydro-1H-1λ6-[1,2,3]oxathiazolo[3,4-a]pyrazine-5(3H)-carboxylate (1450620-52-6)

Guidance literature:

(R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate; With 1H-imidazole; thionyl chloride; In dichloromethane; at -78 - 20 ℃; for 60h;

With ruthenium trichloride; sodium periodate; In acetonitrile; at 0 - 20 ℃; for 120h;

Reference yield: 73.0%

tert-butyl (3aR)-1,1-dioxotetrahydro-1H-1λ6-[1,2,3]oxathiazolo[3,4-a]pyrazine-5(3H)-carboxylate (1450620-52-6) + sodium 4-bromo-5-chloro-2-(hydroxymethyl)-3-methylbenzoate → 4-bromo-2-[[(2R)-4-tert-butoxycarbonylpiperazin-2-yl]methoxymethyl]-5-chloro-3-methylbenzoic acid hydrochloride

Guidance literature:

sodium 4-bromo-5-chloro-2-(hydroxymethyl)-3-methylbenzoate; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; paraffin oil; at 0 ℃; for 0.166667h;

tert-butyl (3aR)-1,1-dioxotetrahydro-1H-1λ⁶-[1,2,3]oxathiazolo[3,4-a]pyrazine-5(3H)-carboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; at 0 - 20 ℃; for 15h;

With hydrogenchloride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield: 71.0%

2-fluorophenol (367-12-4) + tert-butyl (3aR)-1,1-dioxotetrahydro-1H-1λ6-[1,2,3]oxathiazolo[3,4-a]pyrazine-5(3H)-carboxylate (1450620-52-6) → (R)-3-(2-fluorophenoxymethyl)piperazine-1-carboxylic acid tert-butyl ester (1589081-71-9)

Guidance literature:

2-fluorophenol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

tert-butyl (3aR)-1,1-dioxotetrahydro-1H-1λ⁶-[1,2,3]oxathiazolo[3,4-a]pyrazine-5(3H)-carboxylate; In N,N-dimethyl-formamide; at 50 ℃;

With hydrogenchloride; In water; N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

upstream raw materials:

(R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate

Downstream raw materials:

tert-butyl (3S)-3-((4-(tert-butoxycarbonyl)tetrahydro-2H-pyran-4-yl)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinecarboxylate

tert-butyl (3S)-3-((4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinecarboxylate

1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-((4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)methyl)-1-piperazinyl)phenyl)-2-propanol hydrochloride

tert-butyl (5-(((3S)-3-((4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1450620-52-6 tert-butyl (3aR)-1,1-dioxotetrahydro-1H-1λ⁶-[1,2,3]oxathiazolo[3,4-a]pyrazine-5(3H)-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send