(2S,3S)-3-N-(tert-butoxycarbonyl)amino-2-(4-bromophenyl)-4-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide

Base Information

Chemical Name:(2S,3S)-3-N-(tert-butoxycarbonyl)amino-2-(4-bromophenyl)-4-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide
CAS No.:899429-08-4
Molecular Formula:C₂₁H₃₀BrN₃O₄
Molecular Weight:468.391
Hs Code.:

Synonyms:(2S,3S)-3-N-(tert-butoxycarbonyl)amino-2-(4-bromophenyl)-4-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide

Suppliers and Price of (2S,3S)-3-N-(tert-butoxycarbonyl)amino-2-(4-bromophenyl)-4-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S)-3-N-(tert-butoxycarbonyl)amino-2-(4-bromophenyl)-4-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S)-3-N-(tert-butoxycarbonyl)amino-2-(4-bromophenyl)-4-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide

There total 1 articles about (2S,3S)-3-N-(tert-butoxycarbonyl)amino-2-(4-bromophenyl)-4-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,3S)-2-(4-Bromo-phenyl)-3-tert-butoxycarbonylamino-4-oxo-4-pyrrolidin-1-yl-butyric acid

: 124-40-3
dimethyl amine

: 899429-08-4
(2S,3S)-3-N-(tert-butoxycarbonyl)amino-2-(4-bromophenyl)-4-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm060015t

Reference yield:

: 899429-08-4
(2S,3S)-3-N-(tert-butoxycarbonyl)amino-2-(4-bromophenyl)-4-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide

: 73183-34-3
bis(pinacol)diborane

: 899429-10-8
{(1S,2S)-2-Dimethylcarbamoyl-1-(pyrrolidine-1-carbonyl)-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃;
DOI:10.1021/jm060015t

Reference yield:

: 899429-08-4
(2S,3S)-3-N-(tert-butoxycarbonyl)amino-2-(4-bromophenyl)-4-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide

: [2-dimethylcarbamoyl-1-(pyrrolidine-1-carbonyl)-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-phenyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: [1,1'-bis(diphenylphosphino)ferrocene]PdCl₂*CH₂Cl₂; AcOK / dimethylsulfoxide / 80 °C

2: [1,1'-bis(diphenylphosphino)ferrocene]PdCl₂*CH₂Cl₂; aq. Na₂CO₃ / ethanol; toluene / 90 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium carbonate; In ethanol; dimethyl sulfoxide; toluene; 2: Suzuki coupling;
DOI:10.1021/jm060015t