Technology Process of (cis-3,4-dihydroxypyrrolidin-1-yl)-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridin-3-yl]methanone
There total 6 articles about (cis-3,4-dihydroxypyrrolidin-1-yl)-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridin-3-yl]methanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 20h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / 20 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C
With
diethylamino-sulfur trifluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / 0.5 h / Reflux
1.2: 0 - 10 °C / pH 1
2.1: lithium diisopropyl amide / tetrahydrofuran; hexanes / 0 °C
2.2: 0 - 65 °C
2.3: 0 °C
3.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / 20 °C
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C
With
diethylamino-sulfur trifluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; hexanes; dichloromethane; N,N-dimethyl-formamide;
