meso-N-(2-fluoro-4-iodophenyl)-3-[(3aR,6aS)-tetrahydro-5H-spiro[1,3-dioxolo[4,5-c]pyrrole-2,4'-piperidin]-5-ylcarbonyl]thieno[2,3-b]pyridin-2-amine

Base Information

Chemical Name:meso-N-(2-fluoro-4-iodophenyl)-3-[(3aR*,6aS*)-tetrahydro-5H-spiro[1,3-dioxolo[4,5-c]pyrrole-2,4'-piperidin]-5-ylcarbonyl]thieno[2,3-b]pyridin-2-amine
CAS No.:1202067-02-4
Molecular Formula:C₂₃H₂₂FIN₄O₃S
Molecular Weight:580.422
Hs Code.:

Synonyms:meso-N-(2-fluoro-4-iodophenyl)-3-[(3aR*,6aS*)-tetrahydro-5H-spiro[1,3-dioxolo[4,5-c]pyrrole-2,4'-piperidin]-5-ylcarbonyl]thieno[2,3-b]pyridin-2-amine

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Chemical Property of meso-N-(2-fluoro-4-iodophenyl)-3-[(3aR*,6aS*)-tetrahydro-5H-spiro[1,3-dioxolo[4,5-c]pyrrole-2,4'-piperidin]-5-ylcarbonyl]thieno[2,3-b]pyridin-2-amine

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Technology Process of meso-N-(2-fluoro-4-iodophenyl)-3-[(3aR*,6aS*)-tetrahydro-5H-spiro[1,3-dioxolo[4,5-c]pyrrole-2,4'-piperidin]-5-ylcarbonyl]thieno[2,3-b]pyridin-2-amine

There total 7 articles about meso-N-(2-fluoro-4-iodophenyl)-3-[(3aR*,6aS*)-tetrahydro-5H-spiro[1,3-dioxolo[4,5-c]pyrrole-2,4'-piperidin]-5-ylcarbonyl]thieno[2,3-b]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1202067-35-3
(cis-3,4-dihydroxypyrrolidin-1-yl)-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridin-3-yl]methanone

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1202067-02-4
meso-N-(2-fluoro-4-iodophenyl)-3-[(3aR*,6aS*)-tetrahydro-5H-spiro[1,3-dioxolo[4,5-c]pyrrole-2,4'-piperidin]-5-ylcarbonyl]thieno[2,3-b]pyridin-2-amine

Guidance literature:: (cis-3,4-dihydroxypyrrolidin-1-yl)-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridin-3-yl]methanone; N-tert-butyloxycarbonylpiperidin-4-one; With toluene-4-sulfonic acid; In toluene; for 4h; Reflux;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 1174730-72-3
2-[(2-fluoro-4-iodophenyl)amino]thieno[2,3-b]pyridine-3-carbonyl fluoride

: 1202067-02-4
meso-N-(2-fluoro-4-iodophenyl)-3-[(3aR*,6aS*)-tetrahydro-5H-spiro[1,3-dioxolo[4,5-c]pyrrole-2,4'-piperidin]-5-ylcarbonyl]thieno[2,3-b]pyridin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

2: toluene-4-sulfonic acid / toluene / 4 h / Reflux

With benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 101012-32-2
2-(2-chloropyridin-3-yl)acetonitrile

: 1202067-02-4
meso-N-(2-fluoro-4-iodophenyl)-3-[(3aR*,6aS*)-tetrahydro-5H-spiro[1,3-dioxolo[4,5-c]pyrrole-2,4'-piperidin]-5-ylcarbonyl]thieno[2,3-b]pyridin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / 0.5 h / Reflux

1.2: 0 - 10 °C / pH 1

2.1: lithium diisopropyl amide / tetrahydrofuran; hexanes / 0 °C

2.2: 0 - 65 °C

2.3: 0 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

5.1: toluene-4-sulfonic acid / toluene / 4 h / Reflux

With diethylamino-sulfur trifluoride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; hexanes; dichloromethane; N,N-dimethyl-formamide; toluene;