1174730-72-3

Upstream product

• 945530-36-9 2-((2-fluoro-4-iodophenyl)amino)thieno[2,3-b]pyridine-3-carboxylic acid 
• 42330-59-6 (2-chloropyrid-3-yl)methanol 
• 89581-84-0 2-chloro-3-(chloromethyl)pyridine 
• 101012-32-2 2-(2-chloropyridin-3-yl)acetonitrile 

Downstream Products

• 1174730-60-9 2-({2-[(2-fluoro-4-iodophenyl)amino]thieno[2,3-b]pyridin-3-yl}carbonyl)isoxazolidin-4-ol 
• 1174730-62-1 (4S)-2-({2-[(2-fluoro-4-iodophenyl)amino]thieno[2,3-b]pyridin-3-yl}carbonyl)isoxazolidin-4-ol 
• 1174730-61-0 (4R)-2-({2-[(2-fluoro-4-iodophenyl)amino]thieno[2,3-b]pyridin-3-yl}carbonyl)isoxazolidin-4-ol 
• 1174730-76-7 [(S)-4-azidoisoxazolidin-2-yl][2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridin-3-yl]methanone 
• 1174730-67-6 2-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridine-3-carbonyl]-5-methyl-isoxazolidine-5-carboxylic acid methyl ester 
• 1174730-70-1 benzyl 1-({2-[(2-fluoro-4-iodophenyl)amino]thieno[2,3-b]pyridin-3-yl}carbonyl)-tetrahydro-1H-pyrrolo[3,4-c]isoxazole-5(3H)-carboxylate 
• 1202067-05-7 cis-(3,6)-5-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridine-3-carbonyl]-hexahydropyrrolo[3,4-d]imidazol-2-one 
• 1202067-06-8 [(3aS,6aR)-2-amino-3a,4,6,6a-tetrahydropyrrolo[3,4-d]thiazol-5-yl]-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridin-3-yl]-methanone 
• 1202067-07-9 [(3aS,6aR)-2-(cyclopropylamino)-3a,4,6,6a-tetrahydropyrrolo[3,4-d]thiazol-5-yl]-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridin-3-yl]-methanone 
• 1202067-08-0 [(3aS,6aR)-2-amino-3a,4,6,6a-tetrahydropyrrolo[3,4-d]oxazol-5-yl]-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridin-3-yl]-methanone 
• 1202067-13-7 N-(2-fluoro-4-iodophenyl)-3-[(2-methyl-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)carbonyl] thieno[2,3-b]pyridin-2-amine 
• 1202067-14-8 N-(2-fluoro-4-iodophenyl)-3-{[cis-(3,6)-2-phenyl-3a,4,6,6a-tetrahydropyrrolo[3,4-d]imidazol-5(1H)-yI] carbonyl}thieno[2,3-b]pyridin-2-amine 
• 1202067-15-9 N-(2-fluoro-4-iodophenyl)-3-{[cis-(3,6)-2-isopropyl-3a,4,6,6a-tetrahydropyrrolo[3,4-d]imidazol-5(1H)-yl]carbonyl}thieno[2,3-b]pyridin-2-amine 
• 1202067-16-0 3-([cis-(3,6)-2-(tert-butyl)-3a,4,6,6a-tetrahydropyrrolo[3,4-d]imidazol-5(1H)-yl]carbonyl)-N-(2-fluoro-4-iodophenyl)thieno[2,3-b]pyridin-2-amine 

Relevant academic research and scientific papers

THIENO-PYRIDINE DERIVATIVES AS MEK INHIBITORS

A series of thieno[2,3-6]pyridine derivatives, attached at the 2-position to a substituted anilino moiety, which are substituted in the 3-position by a carbonyl group linked to a pyrrolidin-1-yl ring which in turn forms part of a heteroatom-containing fus

THIENO-PYRIDINE DERIVATIVES AS MEK INHIBITORS

The invention provides a series of thieno[2,3-b]pyridine derivatives wherein Y represents a linkage of formula C(O) or S(O)2; R1 represents hydrogen, halogen, cyano, nitro, C|-6 alkyl, trifluoromethyl, Ci.6 alkoxy, trifluoromethoxy,