methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]glycinate

Base Information

Chemical Name:methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]glycinate
CAS No.:165952-41-0
Molecular Formula:C₁₇H₁₆Cl₂N₂O₄
Molecular Weight:383.231
Hs Code.:

Synonyms:methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]glycinate

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Chemical Property of methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]glycinate

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Technology Process of methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]glycinate

There total 5 articles about methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 165952-40-9
5-chloro-α-(2-chlorophenyl)-2-nitrophenylacetaldehyde

: 165952-41-0
methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]glycinate

Guidance literature:: glycine ethyl ester hydrochloride; 5-chloro-α-(2-chlorophenyl)-2-nitrophenylacetaldehyde; With sodium acetate; In methanol; at 20 ℃; for 0.5h;

With sodium cyanoborohydride; In methanol; at 50 ℃; for 3h;
DOI:10.1016/S0968-0896(01)00289-9

Reference yield:

: 57486-68-7
methyl (2-chlorophenyl)acetate

: 165952-41-0
methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]glycinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 58 percent / NaH / dimethylformamide / 1 h / 0 °C

2.1: 46 percent / LiBH₄ / tetrahydrofuran / 4 h / 20 °C

3.1: 83 percent / DMSO; oxalyl chloride; NEt₃ / CH₂Cl₂ / -78 - 0 °C

4.1: NaOAc / methanol / 0.5 h / 20 °C

4.2: 52 percent / NaBH₃CN / methanol / 3 h / 50 °C

With lithium borohydride; oxalyl dichloride; sodium acetate; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Swern oxidation;
DOI:10.1016/S0968-0896(01)00289-9

Reference yield:

: 610-40-2
3,4-dinitro-chlorobenzene

: 165952-41-0
methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]glycinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 58 percent / NaH / dimethylformamide / 1 h / 0 °C

2.1: 46 percent / LiBH₄ / tetrahydrofuran / 4 h / 20 °C

3.1: 83 percent / DMSO; oxalyl chloride; NEt₃ / CH₂Cl₂ / -78 - 0 °C

4.1: NaOAc / methanol / 0.5 h / 20 °C

4.2: 52 percent / NaBH₃CN / methanol / 3 h / 50 °C

With lithium borohydride; oxalyl dichloride; sodium acetate; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Swern oxidation;
DOI:10.1016/S0968-0896(01)00289-9