methyl N-[2-(5-chloro-2-neopentylaminophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate

Base Information

Chemical Name:methyl N-[2-(5-chloro-2-neopentylaminophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate
CAS No.:165952-44-3
Molecular Formula:C₂₄H₂₇Cl₂F₃N₂O₃
Molecular Weight:519.391
Hs Code.:

Synonyms:methyl N-[2-(5-chloro-2-neopentylaminophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate

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Chemical Property of methyl N-[2-(5-chloro-2-neopentylaminophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate

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Technology Process of methyl N-[2-(5-chloro-2-neopentylaminophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate

There total 8 articles about methyl N-[2-(5-chloro-2-neopentylaminophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 630-19-3
pivalaldehyde

: 165952-43-2
methyl N-[2-(2-amino-5-chlorophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate

: 165952-44-3
methyl N-[2-(5-chloro-2-neopentylaminophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate

Guidance literature:: pivalaldehyde; methyl N-[2-(2-amino-5-chlorophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate; With acetic acid; In methanol; at 20 ℃; for 0.5h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 1h;
DOI:10.1016/S0968-0896(01)00289-9

Reference yield:

: 57486-68-7
methyl (2-chlorophenyl)acetate

: 165952-44-3
methyl N-[2-(5-chloro-2-neopentylaminophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 58 percent / NaH / dimethylformamide / 1 h / 0 °C

2.1: 46 percent / LiBH₄ / tetrahydrofuran / 4 h / 20 °C

3.1: 83 percent / DMSO; oxalyl chloride; NEt₃ / CH₂Cl₂ / -78 - 0 °C

4.1: NaOAc / methanol / 0.5 h / 20 °C

4.2: 52 percent / NaBH₃CN / methanol / 3 h / 50 °C

5.1: 96 percent / pyridine / CH₂Cl₂ / 0.17 h / 20 °C

6.1: 42 percent / H₂ / 10 percent Pd-C / ethyl acetate / 8 h / 20 °C

7.1: AcOH / methanol / 0.5 h / 20 °C

7.2: 60 percent / NaBH₃CN / methanol / 1 h / 20 °C

With pyridine; lithium borohydride; oxalyl dichloride; hydrogen; sodium acetate; sodium hydride; acetic acid; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 3.1: Swern oxidation;
DOI:10.1016/S0968-0896(01)00289-9

Reference yield:

: 610-40-2
3,4-dinitro-chlorobenzene

: 165952-44-3
methyl N-[2-(5-chloro-2-neopentylaminophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 58 percent / NaH / dimethylformamide / 1 h / 0 °C

2.1: 46 percent / LiBH₄ / tetrahydrofuran / 4 h / 20 °C

3.1: 83 percent / DMSO; oxalyl chloride; NEt₃ / CH₂Cl₂ / -78 - 0 °C

4.1: NaOAc / methanol / 0.5 h / 20 °C

4.2: 52 percent / NaBH₃CN / methanol / 3 h / 50 °C

5.1: 96 percent / pyridine / CH₂Cl₂ / 0.17 h / 20 °C

6.1: 42 percent / H₂ / 10 percent Pd-C / ethyl acetate / 8 h / 20 °C

7.1: AcOH / methanol / 0.5 h / 20 °C

7.2: 60 percent / NaBH₃CN / methanol / 1 h / 20 °C

With pyridine; lithium borohydride; oxalyl dichloride; hydrogen; sodium acetate; sodium hydride; acetic acid; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 3.1: Swern oxidation;
DOI:10.1016/S0968-0896(01)00289-9