methyl N-[2-(2-amino-5-chlorophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate

Base Information

Chemical Name:methyl N-[2-(2-amino-5-chlorophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate
CAS No.:165952-43-2
Molecular Formula:C₁₉H₁₇Cl₂F₃N₂O₃
Molecular Weight:449.257
Hs Code.:

Synonyms:methyl N-[2-(2-amino-5-chlorophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate

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Chemical Property of methyl N-[2-(2-amino-5-chlorophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate

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Technology Process of methyl N-[2-(2-amino-5-chlorophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate

There total 7 articles about methyl N-[2-(2-amino-5-chlorophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 165952-42-1
methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]-N-trifluoroacetylglycinate

: 165952-43-2
methyl N-[2-(2-amino-5-chlorophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 8h;
DOI:10.1016/S0968-0896(01)00289-9

Reference yield:

: 57486-68-7
methyl (2-chlorophenyl)acetate

: 165952-43-2
methyl N-[2-(2-amino-5-chlorophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 58 percent / NaH / dimethylformamide / 1 h / 0 °C

2.1: 46 percent / LiBH₄ / tetrahydrofuran / 4 h / 20 °C

3.1: 83 percent / DMSO; oxalyl chloride; NEt₃ / CH₂Cl₂ / -78 - 0 °C

4.1: NaOAc / methanol / 0.5 h / 20 °C

4.2: 52 percent / NaBH₃CN / methanol / 3 h / 50 °C

5.1: 96 percent / pyridine / CH₂Cl₂ / 0.17 h / 20 °C

6.1: 42 percent / H₂ / 10 percent Pd-C / ethyl acetate / 8 h / 20 °C

With pyridine; lithium borohydride; oxalyl dichloride; hydrogen; sodium acetate; sodium hydride; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 3.1: Swern oxidation;
DOI:10.1016/S0968-0896(01)00289-9

Reference yield:

: 610-40-2
3,4-dinitro-chlorobenzene

: 165952-43-2
methyl N-[2-(2-amino-5-chlorophenyl)-2-(2-chlorophenyl)ethyl]-N-trifluoroacetylglycinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 58 percent / NaH / dimethylformamide / 1 h / 0 °C

2.1: 46 percent / LiBH₄ / tetrahydrofuran / 4 h / 20 °C

3.1: 83 percent / DMSO; oxalyl chloride; NEt₃ / CH₂Cl₂ / -78 - 0 °C

4.1: NaOAc / methanol / 0.5 h / 20 °C

4.2: 52 percent / NaBH₃CN / methanol / 3 h / 50 °C

5.1: 96 percent / pyridine / CH₂Cl₂ / 0.17 h / 20 °C

6.1: 42 percent / H₂ / 10 percent Pd-C / ethyl acetate / 8 h / 20 °C

With pyridine; lithium borohydride; oxalyl dichloride; hydrogen; sodium acetate; sodium hydride; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 3.1: Swern oxidation;
DOI:10.1016/S0968-0896(01)00289-9