4-[1-Phenyl-1-(1-methylimidazol-4-yl)methylene]piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-[1-Phenyl-1-(1-methylimidazol-4-yl)methylene]piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 761446-27-9
• Molecular Formula: C₂₁H₂₇N₃O₂
• Molecular Weight: 353.464

Synonyms:4-[1-Phenyl-1-(1-methylimidazol-4-yl)methylene]piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-[1-Phenyl-1-(1-methylimidazol-4-yl)methylene]piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-[1-Phenyl-1-(1-methylimidazol-4-yl)methylene]piperidine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-[1-Phenyl-1-(1-methylimidazol-4-yl)methylene]piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4-(1-phenyl-1-iodo)methylene)-piperidine-1-carboxylic acid tert-butyl ester + aqueous KF + N-methyl-4-(tributylstannyl)-1H-imidazole (446285-73-0) + trifuran-2-yl-phosphane (5518-52-5) → 4-[1-Phenyl-1-(1-methylimidazol-4-yl)methylene]piperidine-1-carboxylic acid tert-butyl ester (761446-27-9)

Guidance literature:

tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran;

Reference yield: 50.0%

IPrNEt2 + 4-[1-Phenyl-1-(1-methylimidazol-4-yl)methylene]piperidine-1-carboxylic acid tert-butyl ester (761446-27-9) + 4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-6-azaindol-3-yl-oxoacetic acid hydrochloride salt (761446-42-8) → 1-[4-(1-Phenyl-1-(1-methylimidazol-4-yl)-methylene)-piperidin-1-yl]-2-(4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-6-azaindol-3-yl)-ethane-1,2-dione (761446-09-7)

Guidance literature:

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; trifluoroacetic acid; In dichloromethane; chloroform;

upstream raw materials:

N-methyl-4-(tributylstannyl)-1H-imidazole

trifuran-2-yl-phosphane

Downstream raw materials:

1-[4-(1-Phenyl-1-(1-methylimidazol-4-yl)-methylene)-piperidin-1-yl]-2-(4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-6-azaindol-3-yl)-ethane-1,2-dione

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