3-(benzyloxy)-6-(2-((3,4-dimethoxyphenethyl)amino)-2-oxoethyl)-2-methoxybenzyl acetate

Base Information

Chemical Name:3-(benzyloxy)-6-(2-((3,4-dimethoxyphenethyl)amino)-2-oxoethyl)-2-methoxybenzyl acetate
CAS No.:1429118-48-8
Molecular Formula:C₂₉H₃₃NO₇
Molecular Weight:507.584
Hs Code.:

Synonyms:3-(benzyloxy)-6-(2-((3,4-dimethoxyphenethyl)amino)-2-oxoethyl)-2-methoxybenzyl acetate

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Chemical Property of 3-(benzyloxy)-6-(2-((3,4-dimethoxyphenethyl)amino)-2-oxoethyl)-2-methoxybenzyl acetate

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Technology Process of 3-(benzyloxy)-6-(2-((3,4-dimethoxyphenethyl)amino)-2-oxoethyl)-2-methoxybenzyl acetate

There total 11 articles about 3-(benzyloxy)-6-(2-((3,4-dimethoxyphenethyl)amino)-2-oxoethyl)-2-methoxybenzyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1429118-40-0
2-(4-(benzyloxy)-2-(hydroxymethyl)-3-methoxyphenyl)-N-(3,4-dimethoxyphenethyl)acetamide

: 75-36-5
acetyl chloride

: 1429118-48-8
3-(benzyloxy)-6-(2-((3,4-dimethoxyphenethyl)amino)-2-oxoethyl)-2-methoxybenzyl acetate

Guidance literature:: With dmap; In dichloromethane; at -10 - 0 ℃; for 1h; Reagent/catalyst; Temperature; Inert atmosphere; Large scale;

Reference yield:

: 34918-57-5
methyl 3-bromo-4-hydroxyphenylacetate

: 1429118-48-8
3-(benzyloxy)-6-(2-((3,4-dimethoxyphenethyl)amino)-2-oxoethyl)-2-methoxybenzyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetone / Reflux

2.1: potassium hydroxide; water; copper; copper(II) oxide / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

3.1: phenylboronic acid / toluene / 1 h / Reflux; Dean-Stark

3.2: 46 h / 100 °C / Molecular sieve; Sealed tube

3.3: 2 h / Reflux

4.1: potassium carbonate / acetone / 4 h / Reflux

5.1: ethanol / 14 h / Reflux

6.1: pyridine / dichloromethane / 1.5 h / 0 - 20 °C

With pyridine; water; copper; potassium carbonate; copper(II) oxide; potassium hydroxide; phenylboronic acid; In ethanol; dichloromethane; acetone; toluene;
DOI:10.1016/j.bmc.2012.12.016

Reference yield:

: 101111-25-5
methyl 2-(4-(benzyloxy)-3-bromophenyl)acetate

: 1429118-48-8
3-(benzyloxy)-6-(2-((3,4-dimethoxyphenethyl)amino)-2-oxoethyl)-2-methoxybenzyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; water; copper; copper(II) oxide / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

2.1: phenylboronic acid / toluene / 1 h / Reflux; Dean-Stark

2.2: 46 h / 100 °C / Molecular sieve; Sealed tube

2.3: 2 h / Reflux

3.1: potassium carbonate / acetone / 4 h / Reflux

4.1: ethanol / 14 h / Reflux

5.1: pyridine / dichloromethane / 1.5 h / 0 - 20 °C

With pyridine; water; copper; potassium carbonate; copper(II) oxide; potassium hydroxide; phenylboronic acid; In ethanol; dichloromethane; acetone; toluene;
DOI:10.1016/j.bmc.2012.12.016