tert-butyl (S)-1-[[3-(benzyloxycarbonyl)amino]propylcarbamoyl]-2-phenylethylcarbamate

Base Information

Chemical Name:tert-butyl (S)-1-[[3-(benzyloxycarbonyl)amino]propylcarbamoyl]-2-phenylethylcarbamate
CAS No.:168827-59-6
Molecular Formula:C₂₅H₃₃N₃O₅
Molecular Weight:455.554
Hs Code.:

Synonyms:tert-butyl (S)-1-[[3-(benzyloxycarbonyl)amino]propylcarbamoyl]-2-phenylethylcarbamate

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Chemical Property of tert-butyl (S)-1-[[3-(benzyloxycarbonyl)amino]propylcarbamoyl]-2-phenylethylcarbamate

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Technology Process of tert-butyl (S)-1-[[3-(benzyloxycarbonyl)amino]propylcarbamoyl]-2-phenylethylcarbamate

There total 2 articles about tert-butyl (S)-1-[[3-(benzyloxycarbonyl)amino]propylcarbamoyl]-2-phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 17400-34-9
(3-aminopropyl)carbamic acid benzyl ester hydrochloride

: 168827-59-6
tert-butyl (S)-1-[[3-(benzyloxycarbonyl)amino]propylcarbamoyl]-2-phenylethylcarbamate

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/j.tetlet.2008.01.137

Reference yield:

: 46460-73-5
N-benzyloxycarbonyl-1,3-diaminopropane

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 168827-59-6
tert-butyl (S)-1-[[3-(benzyloxycarbonyl)amino]propylcarbamoyl]-2-phenylethylcarbamate

Guidance literature:: N-tert-butoxycarbonyl-L-phenylalanine; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 0.25h;

N-benzyloxycarbonyl-1,3-diaminopropane; In N,N-dimethyl-formamide;

Reference yield: 90.0%

: 168827-59-6
tert-butyl (S)-1-[[3-(benzyloxycarbonyl)amino]propylcarbamoyl]-2-phenylethylcarbamate

: 51673-84-8
dimethoxyacetaldehyde

: 1021393-35-0
(S)-2-(2,2-dimethoxyethylamino)-N-(3-(benzyloxycarbonylamino)propyl)-3-phenylpropanamide

Guidance literature:: tert-butyl (S)-1-[[3-(benzyloxycarbonyl)amino]propylcarbamoyl]-2-phenylethylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

dimethoxyacetaldehyde; In tetrahydrofuran; water; at 20 ℃; for 2h;

With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; water; at 20 ℃; Further stages.;
DOI:10.1016/j.tetlet.2008.01.137