1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid

Base Information

Chemical Name:1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid
CAS No.:1280206-31-6
Molecular Formula:C₂₉H₂₇NO₃S
Molecular Weight:469.604
Hs Code.:

Synonyms:1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid

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Chemical Property of 1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid

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Technology Process of 1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid

There total 3 articles about 1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1280206-32-7
1-[4'-(3-methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

: 1280206-31-6
1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid

Guidance literature:: 1-[4'-(3-methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester; With water; lithium hydroxide; In methanol; at 70 ℃; for 3h;

In methanol; Acidic conditions;

Reference yield:

: 1280206-27-0
1-[4'-(4-hydroxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

: 1280206-31-6
1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: phosphorus tribromide / 1,2-dimethoxyethane / 0 - 20 °C

1.2: pH 7

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

3.1: water; lithium hydroxide / methanol / 3 h / 70 °C

3.2: Acidic conditions

With water; phosphorus tribromide; sodium hydride; lithium hydroxide; In methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1280206-29-2
1-[4'-(4-bromomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

: 1280206-31-6
1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

2.1: water; lithium hydroxide / methanol / 3 h / 70 °C

2.2: Acidic conditions

With water; sodium hydride; lithium hydroxide; In methanol; N,N-dimethyl-formamide; mineral oil;