N-[1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarbonyl]-methanesulfonamide

Base Information

Chemical Name:N-[1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarbonyl]-methanesulfonamide
CAS No.:1280208-32-3
Molecular Formula:C₃₀H₃₀N₂O₄S₂
Molecular Weight:546.711
Hs Code.:

Synonyms:N-[1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarbonyl]-methanesulfonamide

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Chemical Property of N-[1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarbonyl]-methanesulfonamide

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Technology Process of N-[1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarbonyl]-methanesulfonamide

There total 4 articles about N-[1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarbonyl]-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3144-09-0
methanesulfonamide

: 1280206-31-6
1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid

: 530-62-1
1,1'-carbonyldiimidazole

: 1280208-32-3
N-[1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarbonyl]-methanesulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; Reflux;

Reference yield:

: 1280206-27-0
1-[4'-(4-hydroxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

: 1280208-32-3
N-[1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarbonyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus tribromide / 1,2-dimethoxyethane / 0 - 20 °C

1.2: pH 7

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

3.1: water; lithium hydroxide / methanol / 3 h / 70 °C

3.2: Acidic conditions

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / Reflux

With water; phosphorus tribromide; sodium hydride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1280206-29-2
1-[4'-(4-bromomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

: 1280208-32-3
N-[1-[4'-(3-Methyl-4-phenethylsulfanylmethyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarbonyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

2.1: water; lithium hydroxide / methanol / 3 h / 70 °C

2.2: Acidic conditions

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / Reflux

With water; sodium hydride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; mineral oil;