2-(Dimethylamino)-2-methylpropanoic acid hydrochloride

Base Information

• Chemical Name: 2-(Dimethylamino)-2-methylpropanoic acid hydrochloride
• CAS No.: 97874-26-5
• Molecular Formula: C₆H₁₃NO₂*ClH
• Molecular Weight: 167.636
• European Community (EC) Number: 851-769-1
• Mol file: 97874-26-5.mol

Synonyms:97874-26-5;2-(dimethylamino)-2-methylpropanoic acid hydrochloride;N,N,2-Trimethyl-DL-alanine hydrochloride;2-(dimethylamino)-2-methylpropanoic acid;hydrochloride;2-(Dimethylamino)-2-methylpropanoic acid HCl;N,N,2-Trimethyl-DL-alanine HCl;TRIMETHYLALANINE HCL;SCHEMBL3302683;ZSEOXYGSFYWPNA-UHFFFAOYSA-N;XDA87426;n,n,2-trimethylalanine hydrochloride;AKOS016907401;N,N,2-Trimethyl-DL-alaninehydrochloride;HCl 2-[N,N-Dimethylamino]-isobutyric acid;CS-0091398;D75124;EN300-109741;Z1431002715

Chemical Property of 2-(Dimethylamino)-2-methylpropanoic acid hydrochloride

Chemical Property:

• Melting Point: 264 °C (decomp)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 167.0713064
• Heavy Atom Count: 10
• Complexity: 118

Purity/Quality:

98.5% ^*data from raw suppliers

N,N,2-Trimethyl-DL-alanineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C(=O)O)N(C)C.Cl

Technology Process of 2-(Dimethylamino)-2-methylpropanoic acid hydrochloride

There total 2 articles about 2-(Dimethylamino)-2-methylpropanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + formic acid (64-18-6) + 2-Aminoisobutyric acid (62-57-7) → 2-dimethylamino-2-methylpropionic acid hydrochloride (97874-26-5)

Guidance literature:

formaldehyd; formic acid; 2-Aminoisobutyric acid; for 2h; Reflux;

With hydrogenchloride; In water;

Reference yield: 84.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-Aminoisobutyric acid (62-57-7) → 2-dimethylamino-2-methylpropionic acid hydrochloride (97874-26-5)

Guidance literature:

With hydrogenchloride; formic acid; In water; Reflux;

DOI:10.3762/bjoc.8.122

Reference yield: 13.0%

C23H25N3O5S + 2-dimethylamino-2-methylpropionic acid hydrochloride (97874-26-5) → {1-(2-dimethylamino-2-methylpropionyl)-3-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylamino]-azetidin-3-yl}acetic acid methyl ester

Guidance literature:

2-dimethylamino-2-methylpropionic acid hydrochloride; With 2-hydroxy-pyridine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

C₂₃H₂₅N₃O₅S; In dichloromethane; at 20 - 40 ℃; for 8h; Inert atmosphere;

DOI:10.1016/j.bmc.2017.07.054

upstream raw materials:

formaldehyd

formic acid

2-Aminoisobutyric acid

Refernces

• 1、 -. "FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE". Page/Page column 144. . Retrieved 2010/09/18.