Thio-platelet activating factor

Base Information

Chemical Name:Thio-platelet activating factor
CAS No.:89314-81-8
Molecular Formula:C₂₈H₅₈NO₆PS
Molecular Weight:567.811
Hs Code.:
DSSTox Substance ID:DTXSID101008747
ChEMBL ID:CHEMBL167559
Mol file:89314-81-8.mol

Synonyms:2-acetyl-S-octadecyl-1-thioglycero-3-phosphocholine;thio-PAF;thio-platelet activating factor

Suppliers and Price of Thio-platelet activating factor

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Thio-platelet activating factor

Chemical Property:

PSA：120.00000
LogP:8.19080
XLogP3:8.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:28
Exact Mass:567.37224674
Heavy Atom Count:37
Complexity:579

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCCCCCCCCCCCCCCSCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)C

Technology Process of Thio-platelet activating factor

There total 6 articles about Thio-platelet activating factor which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 95256-24-9
Acetic acid 1-octadecylsulfanylmethyl-2-(2-oxo-2λ⁵-[1,3,2]dioxaphospholan-2-yloxy)-ethyl ester

: 75-50-3
trimethylamine

: 89314-81-8
(acetoxy-2 octadecylthio-1) propyl-3 phosphorylcholine

Guidance literature:: In acetonitrile; for 48h;

Reference yield:

: 7400-44-4
octadecylthio-1 propanediol-2,3

: 89314-81-8
(acetoxy-2 octadecylthio-1) propyl-3 phosphorylcholine

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / imidazole / tetrahydrofuran / 24 h / Heating

2: 90 percent / pyridine / CH₂Cl₂ / 24 h / 60 °C

3: 84 percent / d'etherate de trifluorure de bore / CHCl₃ / 1 h / Ambient temperature

4: triethylamine / tetrahydrofuran / 24 h / Ambient temperature

5: 71 percent / acetonitrile / 48 h

With pyridine; 1H-imidazole; boron trifluoride diethyl etherate; triethylamine; In tetrahydrofuran; dichloromethane; chloroform; acetonitrile;

Reference yield:

: 94478-27-0
rac-1-S-octadecyl-3-O-(tert-butyldimethylsilyl)-1-thioglycerol

: 89314-81-8
(acetoxy-2 octadecylthio-1) propyl-3 phosphorylcholine

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / pyridine / CH₂Cl₂ / 24 h / 60 °C

2: 84 percent / d'etherate de trifluorure de bore / CHCl₃ / 1 h / Ambient temperature

3: triethylamine / tetrahydrofuran / 24 h / Ambient temperature

4: 71 percent / acetonitrile / 48 h

With pyridine; boron trifluoride diethyl etherate; triethylamine; In tetrahydrofuran; dichloromethane; chloroform; acetonitrile;