2-amino-6-methoxy-9-[β-D-2'-deoxyribofuranosyl]-7-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

Base Information

Chemical Name:2-amino-6-methoxy-9-[β-D-2'-deoxyribofuranosyl]-7-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine
CAS No.:1372854-61-9
Molecular Formula:C₂₄H₃₁N₅O₇
Molecular Weight:501.539
Hs Code.:

Synonyms:2-amino-6-methoxy-9-[β-D-2'-deoxyribofuranosyl]-7-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

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Chemical Property of 2-amino-6-methoxy-9-[β-D-2'-deoxyribofuranosyl]-7-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

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Technology Process of 2-amino-6-methoxy-9-[β-D-2'-deoxyribofuranosyl]-7-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

There total 9 articles about 2-amino-6-methoxy-9-[β-D-2'-deoxyribofuranosyl]-7-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 67-56-1
methanol

: 1372854-56-2
2-amino-6-chloro-9-[β-D-2’-deoxyribofuranosyl]-7-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

: 1372854-61-9
2-amino-6-methoxy-9-[β-D-2'-deoxyribofuranosyl]-7-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

Guidance literature:: With sodium methylate; In methanol; for 1h; Reflux; Inert atmosphere;

Reference yield: 74.0%

: 1372854-56-2
2-amino-6-chloro-9-[β-D-2’-deoxyribofuranosyl]-7-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

: 124-41-4
sodium methylate

: 1372854-61-9
2-amino-6-methoxy-9-[β-D-2'-deoxyribofuranosyl]-7-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

Guidance literature:: In methanol; for 1h; Reflux; Inert atmosphere;
DOI:10.1002/anie.201106516

Reference yield:

: 1200461-80-8
9-[β-D-3’,5’-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-2-(tert-butyldimethylsilyl)amino-6-chloro-7-iodo-7-deazapurine

: 1372854-61-9
2-amino-6-methoxy-9-[β-D-2'-deoxyribofuranosyl]-7-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

Guidance literature:: Multi-step reaction with 6 steps

1: bis(benzonitrile)palladium(II) dichloride; triethylamine / 1,4-dioxane / 24 h / 58 °C

2: lithium borohydride / tetrahydrofuran; methanol / 1 h / Reflux

3: dmap; methanesulfonyl chloride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

4: 0.75 h / 115 °C / Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

6: methanol / 1 h / Reflux; Inert atmosphere

With dmap; bis(benzonitrile)palladium(II) dichloride; lithium borohydride; tetrabutyl ammonium fluoride; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1002/anie.201106516