1-(2-((2R)-1-[(2-[⁽¹⁸⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine

Base Information

• Chemical Name: 1-(2-((2R)-1-[(2-[⁽¹⁸⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine
• CAS No.: 1314696-37-1
• Molecular Formula: C₁₈H₂₇FN₂O₂S
• Molecular Weight: 353.491

Synonyms:1-(2-((2R)-1-[(2-[⁽¹⁸⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine

Chemical Property of 1-(2-((2R)-1-[(2-[⁽¹⁸⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-((2R)-1-[(2-[⁽¹⁸⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine

There total 6 articles about 1-(2-((2R)-1-[(2-[⁽¹⁸⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-1-(2-((2R)-1-[(2-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperidine (1314696-26-8) → 1-(2-((2R)-1-[(2-[(18)F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine (1314696-37-1)

Guidance literature:

With [¹⁸F]-potassium fluoride; [2.2.2]cryptande; In dimethyl sulfoxide; at 150 ℃; for 0.166667h;

DOI:10.1016/j.ejmech.2011.05.010

Reference yield:

tert-butyl (2R)-2-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]pyrrolidine-1-carboxylate (1314696-16-6) → 1-(2-((2R)-1-[(2-[(18)F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine (1314696-37-1)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 50 °C

3: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

4: [¹⁸F]-potassium fluoride; [2.2.2]cryptande / dimethyl sulfoxide / 0.17 h / 150 °C

With lithium aluminium tetrahydride; [¹⁸F]-potassium fluoride; triethylamine; [2.2.2]cryptande; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2011.05.010

Reference yield:

(R)-2-(pyrrolidin-2-yl)acetic acid (61350-65-0) → 1-(2-((2R)-1-[(2-[(18)F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine (1314696-37-1)

Guidance literature:

Multi-step reaction with 6 steps

1: triethylamine

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 50 °C

5: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

6: [¹⁸F]-potassium fluoride; [2.2.2]cryptande / dimethyl sulfoxide / 0.17 h / 150 °C

With lithium aluminium tetrahydride; [¹⁸F]-potassium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; [2.2.2]cryptande; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.05.010

upstream raw materials:

tert-butyl (2R)-2-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]pyrrolidine-1-carboxylate

4-methyl-1-(2-((2R)-1-[(2-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperidine

2-Nitrobenzenesulfonyl chloride

(R)-2-[2-(4-methyl-piperidin-1-yl)ethyl]pyrrolidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1314696-37-1 1-(2-((2R)-1-[(2-[⁽¹⁸⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send