ethyl (2R)-2-(2-{[2-methoxy-2-(m-tolyl)ethyl]selanyl}phenoxy)propanoate

Base Information

Chemical Name:ethyl (2R)-2-(2-{[2-methoxy-2-(m-tolyl)ethyl]selanyl}phenoxy)propanoate
CAS No.:1361315-63-0
Molecular Formula:C₂₁H₂₆O₄Se
Molecular Weight:421.395
Hs Code.:

Synonyms:ethyl (2R)-2-(2-{[2-methoxy-2-(m-tolyl)ethyl]selanyl}phenoxy)propanoate

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Chemical Property of ethyl (2R)-2-(2-{[2-methoxy-2-(m-tolyl)ethyl]selanyl}phenoxy)propanoate

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Technology Process of ethyl (2R)-2-(2-{[2-methoxy-2-(m-tolyl)ethyl]selanyl}phenoxy)propanoate

There total 3 articles about ethyl (2R)-2-(2-{[2-methoxy-2-(m-tolyl)ethyl]selanyl}phenoxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 67-56-1
methanol

: 100-80-1
3-methylstyrene

: 1361315-54-9
diethyl (2R,2'R)-2,2'-[diselane-1,2-diylbis(2,1-phenyleneoxy)]dipropanoate

: 1361315-63-0
ethyl (2R)-2-(2-{[2-methoxy-2-(m-tolyl)ethyl]selanyl}phenoxy)propanoate

Guidance literature:: diethyl (2R,2'R)-2,2'-[diselane-1,2-diylbis(2,1-phenyleneoxy)]dipropanoate; With bromine; In tetrachloromethane; dichloromethane; at -78 ℃; for 0.333333h; Inert atmosphere;

methanol; With silver trifluoromethanesulfonate; In tetrachloromethane; dichloromethane; at -78 ℃; for 0.5h; Inert atmosphere;

3-methylstyrene; In tetrachloromethane; dichloromethane; at -78 ℃; for 2h; Inert atmosphere;
DOI:10.1002/ejoc.201101373

Reference yield:

: 95-56-7
2-hydroxybromobenzene

: 1361315-63-0
ethyl (2R)-2-(2-{[2-methoxy-2-(m-tolyl)ethyl]selanyl}phenoxy)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / hexane / 2.5 h / -78 - 20 °C / Inert atmosphere

1.2: air / 24 h / 0 - 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 1 h / 0 - 20 °C / Inert atmosphere

3.1: bromine / tetrachloromethane; dichloromethane / 0.33 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

3.3: 2 h / -78 °C / Inert atmosphere

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; di-isopropyl azodicarboxylate; bromine; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; toluene; 2.1: Mitsunobu reaction;
DOI:10.1002/ejoc.201101373

Reference yield:

: 73011-32-2
1,2-bis(2-hydroxyphenyl)diselenide

: 1361315-63-0
ethyl (2R)-2-(2-{[2-methoxy-2-(m-tolyl)ethyl]selanyl}phenoxy)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 1 h / 0 - 20 °C / Inert atmosphere

2.1: bromine / tetrachloromethane; dichloromethane / 0.33 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

2.3: 2 h / -78 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; bromine; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; dichloromethane; toluene; 1.1: Mitsunobu reaction;
DOI:10.1002/ejoc.201101373