2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2,3-c]pyrido[3',2':4,5]pyrrolo[1,2-c][1,3]oxazin-2-yl)benzofuran-3-carboxamide

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Chemical Name:2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2,3-c]pyrido[3',2':4,5]pyrrolo[1,2-c][1,3]oxazin-2-yl)benzofuran-3-carboxamide
CAS No.:1427032-86-7
Molecular Formula:C₃₁H₂₄FN₅O₅S
Molecular Weight:597.626
Hs Code.:

Synonyms:2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2,3-c]pyrido[3',2':4,5]pyrrolo[1,2-c][1,3]oxazin-2-yl)benzofuran-3-carboxamide

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Chemical Property of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2,3-c]pyrido[3',2':4,5]pyrrolo[1,2-c][1,3]oxazin-2-yl)benzofuran-3-carboxamide

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Technology Process of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2,3-c]pyrido[3',2':4,5]pyrrolo[1,2-c][1,3]oxazin-2-yl)benzofuran-3-carboxamide

There total 18 articles about 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2,3-c]pyrido[3',2':4,5]pyrrolo[1,2-c][1,3]oxazin-2-yl)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

: 1427034-53-4
2-chloro-6H-pyrido[2,3-e]pyrido[3',2':4,5]pyrrolo[1,2-c][1,3]oxazine

: 1427032-86-7
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2,3-c]pyrido[3',2':4,5]pyrrolo[1,2-c][1,3]oxazin-2-yl)benzofuran-3-carboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate; XPhos; In 1,4-dioxane; water; at 80 ℃; Inert atmosphere;

Reference yield:

: 271-63-6
7-Azaindole

: 1427032-86-7
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2,3-c]pyrido[3',2':4,5]pyrrolo[1,2-c][1,3]oxazin-2-yl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 2 h / -70 - -45 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate / 1,4-dioxane / 80 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 10 h / 100 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

6.1: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 80 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; potassium phosphate tribasic trihydrate; sodium hydride; potassium carbonate; XPhos; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 879132-46-4
1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

: 1427032-86-7
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2,3-c]pyrido[3',2':4,5]pyrrolo[1,2-c][1,3]oxazin-2-yl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 2 h / -70 - -45 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate / 1,4-dioxane / 80 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 10 h / 100 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

5.1: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 80 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; potassium phosphate tribasic trihydrate; potassium carbonate; XPhos; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;