(CH₃OC₆H₄)2C₆H₅COCH₃CO₂(C₅H₇OC₅N₂H₅O₂)2O₂POCH₃

Base Information

Chemical Name:(CH₃OC₆H₄)2C₆H₅COCH₃CO₂(C₅H₇OC₅N₂H₅O₂)2O₂POCH₃
CAS No.:130277-22-4
Molecular Formula:C₄₄H₄₉N₄O₁₄P
Molecular Weight:888.865
Hs Code.:

(CH<sub>3</sub>OC<sub>6</sub>H<sub>4</sub>)2C<sub>6</sub>H<sub>5</sub>COCH<sub>3</sub>CO<sub>2</sub>(C<sub>5</sub>H<sub>7</sub>OC<sub>5</sub>N<sub>2</sub>H<sub>5</sub>O<sub>2</sub>)2O<sub>2</sub>POCH<sub>3</sub>

Synonyms:(CH₃OC₆H₄)2C₆H₅COCH₃CO₂(C₅H₇OC₅N₂H₅O₂)2O₂POCH₃

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Chemical Property of (CH₃OC₆H₄)2C₆H₅COCH₃CO₂(C₅H₇OC₅N₂H₅O₂)2O₂POCH₃

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Technology Process of (CH₃OC₆H₄)2C₆H₅COCH₃CO₂(C₅H₇OC₅N₂H₅O₂)2O₂POCH₃

There total 4 articles about (CH₃OC₆H₄)2C₆H₅COCH₃CO₂(C₅H₇OC₅N₂H₅O₂)2O₂POCH₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 21090-30-2
3'-O-acetylthymidine

: 151782-47-7
O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-methyl (O-4-nitrophenyl)-phosphate

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 130277-22-4
(CH₃OC₆H₄)2C₆H₅COCH₃CO₂(C₅H₇OC₅N₂H₅O₂)2O₂POCH₃

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;
DOI:10.1016/j.tetlet.2009.06.102

Reference yield: 85.0%

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 3'-O-acetylthymidin-5'-yl methyl N,N-diisopropylphosphoramidite

: 130277-22-4
(CH₃OC₆H₄)2C₆H₅COCH₃CO₂(C₅H₇OC₅N₂H₅O₂)2O₂POCH₃

Guidance literature:: With 1H-tetrazole; In acetonitrile; for 0.333333h; Ambient temperature;
DOI:10.1080/15257779508010681

Reference yield:

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 130277-22-4
(CH₃OC₆H₄)2C₆H₅COCH₃CO₂(C₅H₇OC₅N₂H₅O₂)2O₂POCH₃

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 4,4'-dimethoxytrityl chloride / 1.) pyridine

2: 84 percent / i-Pr₂NEt / CH₂Cl₂ / 1 h / Ambient temperature

3: 85 percent / 1H-tetrazole / acetonitrile / 0.33 h / Ambient temperature

With 1H-tetrazole; 4,4'-dimethoxytrityl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1080/15257779508010681