4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine

Base Information

• Chemical Name: 4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine
• CAS No.: 1140067-25-9
• Molecular Formula: C₂₃H₂₂N₂O₂
• Molecular Weight: 358.44
• Mol file: 1140067-25-9.mol

Synonyms:4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine

Chemical Property of 4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine

There total 5 articles about 4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

p-Aminophenethylamine (13472-00-9) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → 4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine (1140067-25-9)

Guidance literature:

at 20 ℃; regioselective reaction;

DOI:10.1021/jo401778e

Reference yield: 62.0%

(9H-fluoren-9-yl)methyl (4-(2-acetamidoethyl)phenyl)carbamate → 4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine (1140067-25-9)

Guidance literature:

With hydroxylamine trifluoroacetate; In tetrahydrofuran; at 80 ℃; pH=6.5; chemoselective reaction; Sealed tube;

DOI:10.1002/ejoc.201800304

Reference yield: 56.0%

(9H-fluoren-9-yl)methyl (4-(2-(2,5-dimethyl-1H-pyrrol-1-yl)ethyl)phenyl)carbamate → 4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine (1140067-25-9)

Guidance literature:

With hydrogenchloride; In ethanol; at 120 ℃; for 0.5h; Microwave irradiation;

DOI:10.1021/jo401778e

upstream raw materials:

p-Aminophenethylamine

(fluorenylmethoxy)carbonyl chloride

4-(2-(((methyl)carbonyl)amino)ethyl)aniline

Downstream raw materials:

4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine hydrochloride