diethyl 1,4-dihydro-2-methyl-4-(3-nitrophenyl)-6-(trifluoromethyl)-pyridine-3,5-dicarboxylate

Base Information

Chemical Name:diethyl 1,4-dihydro-2-methyl-4-(3-nitrophenyl)-6-(trifluoromethyl)-pyridine-3,5-dicarboxylate
CAS No.:95400-30-9
Molecular Formula:C₁₉H₁₉F₃N₂O₆
Molecular Weight:428.365
Hs Code.:

Synonyms:diethyl 1,4-dihydro-2-methyl-4-(3-nitrophenyl)-6-(trifluoromethyl)-pyridine-3,5-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 1,4-dihydro-2-methyl-4-(3-nitrophenyl)-6-(trifluoromethyl)-pyridine-3,5-dicarboxylate

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Technology Process of diethyl 1,4-dihydro-2-methyl-4-(3-nitrophenyl)-6-(trifluoromethyl)-pyridine-3,5-dicarboxylate

There total 4 articles about diethyl 1,4-dihydro-2-methyl-4-(3-nitrophenyl)-6-(trifluoromethyl)-pyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 99-61-6
3-nitro-benzaldehyde

: 626-34-6,7318-00-5,41867-20-3
ethyl aminocrotonate

: 372-31-6
ethyl 4,4,4-trifluoroacetoacetate

: 95400-30-9
diethyl 1,4-dihydro-2-methyl-4-(3-nitrophenyl)-6-(trifluoromethyl)-pyridine-3,5-dicarboxylate

Guidance literature:: In ethanol; at 90 ℃;
DOI:10.1016/S0006-2952(02)01488-0

Reference yield:

: Diethyl 1,2,3,4-tetrahydro-2-hydroxy-6-methyl-4-(3-nitrophenyl)-2-(trifluoromethyl)-3,5-pyridine-dicarboxylate

: 95400-30-9
diethyl 1,4-dihydro-2-methyl-4-(3-nitrophenyl)-6-(trifluoromethyl)-pyridine-3,5-dicarboxylate

Guidance literature:: With trichlorophosphate; In dichloromethane; for 6h; Heating;
DOI:10.3987/COM-06-10827

Reference yield:

: 41867-20-3
ethyl (E)-3-aminobut-2-enoate

: 95400-30-9
diethyl 1,4-dihydro-2-methyl-4-(3-nitrophenyl)-6-(trifluoromethyl)-pyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / Heating

2: phosphorus oxychloride; pyridine absorbed on silica gel / CH₂Cl₂ / 6 h / Heating

With trichlorophosphate; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.3987/COM-06-10827