N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

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Chemical Name:N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine
CAS No.:1350648-56-4
Molecular Formula:C₂₅H₂₀ClFN₆O
Molecular Weight:474.925
Hs Code.:

Synonyms:N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

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Chemical Property of N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

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Technology Process of N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

There total 6 articles about N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350648-20-2
7-iodo-1H-pyrazolo[4,3-b]pyridine

: 1350648-38-2
2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-amine

: 824-94-2
p-methoxybenzyl chloride

: 1350648-56-4
N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

: 1350648-55-3
N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-7-amine

Guidance literature:: 7-iodo-1H-pyrazolo[4,3-b]pyridine; With sodium hydride; In N,N-dimethyl-formamide; for 0.166667h;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; for 0.5h; Cooling with ice;

2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-amine; With (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate; palladium diacetate; In toluene; at 100 ℃; Inert atmosphere;

Reference yield:

: 14394-70-8
2-chloro-4-amino-5-methylpyrimidine

: 1350648-56-4
N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

: 1350648-55-3
N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-7-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane / 1 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

2.2: 0.5 h / Cooling with ice

2.3: 100 °C / Inert atmosphere

With sodium hydride; sodium carbonate; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 352535-83-2
5-chloro-2-fluorophenylboronic acid

: 1350648-56-4
N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

: 1350648-55-3
N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-7-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane / 1 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

2.2: 0.5 h / Cooling with ice

2.3: 100 °C / Inert atmosphere

With sodium hydride; sodium carbonate; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; N,N-dimethyl-formamide;