N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-7-amine

Base Information

• Chemical Name: N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-7-amine
• CAS No.: 1350648-55-3
• Molecular Formula: C₂₅H₂₀ClFN₆O
• Molecular Weight: 474.925
• Mol file: 1350648-55-3.mol

Synonyms:N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-7-amine

Chemical Property of N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-7-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-7-amine

There total 6 articles about N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-iodo-1H-pyrazolo[4,3-b]pyridine (1350648-20-2) + 2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-amine (1350648-38-2) + p-methoxybenzyl chloride (824-94-2) → N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine (1350648-56-4) + N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-7-amine (1350648-55-3)

Guidance literature:

7-iodo-1H-pyrazolo[4,3-b]pyridine; With sodium hydride; In N,N-dimethyl-formamide; for 0.166667h;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; for 0.5h; Cooling with ice;

2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-amine; With (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate; palladium diacetate; In toluene; at 100 ℃; Inert atmosphere;

Reference yield:

2-chloro-4-amino-5-methylpyrimidine (14394-70-8) → N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine (1350648-56-4) + N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-7-amine (1350648-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane / 1 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

2.2: 0.5 h / Cooling with ice

2.3: 100 °C / Inert atmosphere

With sodium hydride; sodium carbonate; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

5-chloro-2-fluorophenylboronic acid (352535-83-2) → N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine (1350648-56-4) + N-(2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-7-amine (1350648-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane / 1 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

2.2: 0.5 h / Cooling with ice

2.3: 100 °C / Inert atmosphere

With sodium hydride; sodium carbonate; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

7-iodo-1H-pyrazolo[4,3-b]pyridine

2-(5-chloro-2-fluorophenyl)-5-methylpyrimidin-4-amine

p-methoxybenzyl chloride

2-chloro-4-amino-5-methylpyrimidine