1-(4-fluorobenzyl)-4,5-dihydro-2-(4-fluorophenyl)-1H-imidazole

Base Information

• Chemical Name: 1-(4-fluorobenzyl)-4,5-dihydro-2-(4-fluorophenyl)-1H-imidazole
• CAS No.: 1227469-22-8
• Molecular Formula: C₁₆H₁₄F₂N₂
• Molecular Weight: 272.297
• Mol file: 1227469-22-8.mol

Synonyms:1-(4-fluorobenzyl)-4,5-dihydro-2-(4-fluorophenyl)-1H-imidazole

Chemical Property of 1-(4-fluorobenzyl)-4,5-dihydro-2-(4-fluorophenyl)-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-fluorobenzyl)-4,5-dihydro-2-(4-fluorophenyl)-1H-imidazole

There total 2 articles about 1-(4-fluorobenzyl)-4,5-dihydro-2-(4-fluorophenyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-fluorobenzaldehyde (459-57-4) + ethylenediamine (107-15-3,85404-18-8) → 1-(4-fluorobenzyl)-4,5-dihydro-2-(4-fluorophenyl)-1H-imidazole (1227469-22-8)

Guidance literature:

With poly(N-vinylpyrrolidone) capping copper nanoparticle; In neat (no solvent); at 110 ℃; for 0.0333333h; Reagent/catalyst; Microwave irradiation; Green chemistry;

DOI:10.1002/jhet.1551

Reference yield:

N,N'-(ethane-1,2-diyl)bis(1-(4-fluorophenyl)methanimine) (1648-04-0) → 1-(4-fluorobenzyl)-4,5-dihydro-2-(4-fluorophenyl)-1H-imidazole (1227469-22-8)

Guidance literature:

With sulfuric acid; In ethanol; for 4h; Heating;

DOI:10.1002/jhet.314

upstream raw materials:

N,N'-(ethane-1,2-diyl)bis(1-(4-fluorophenyl)methanimine)

4-fluorobenzaldehyde

ethylenediamine