N,N'-Bis-(4-fluorobenzylidene)-ethylenediamine

Base Information

• Chemical Name: N,N'-Bis-(4-fluorobenzylidene)-ethylenediamine
• CAS No.: 1648-04-0
• Molecular Formula: C₁₆H₁₄F₂N₂
• Molecular Weight: 272.297
• European Community (EC) Number: 651-972-3
• Nikkaji Number: J2.911.998H
• Mol file: 1648-04-0.mol

Synonyms:N,N'-BIS-(4-FLUOROBENZYLIDENE)-ETHYLENEDIAMINE;SCHEMBL19439614;AKOS024333572;N,N'-Ethylenebis(4-fluorobenzenemethaneimine)

Chemical Property of N,N'-Bis-(4-fluorobenzylidene)-ethylenediamine

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 272.11250478
• Heavy Atom Count: 20
• Complexity: 282

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1C=NCCN=CC2=CC=C(C=C2)F)F

Technology Process of N,N'-Bis-(4-fluorobenzylidene)-ethylenediamine

There total 1 articles about N,N'-Bis-(4-fluorobenzylidene)-ethylenediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-fluorobenzaldehyde (459-57-4) + ethylenediamine (107-15-3,85404-18-8) → N,N'-(ethane-1,2-diyl)bis(1-(4-fluorophenyl)methanimine) (1648-04-0)

Guidance literature:

In ethanol; at 20 ℃; for 6h;

DOI:10.1016/j.bmc.2019.02.051

Reference yield: 88.0%

N,N'-(ethane-1,2-diyl)bis(1-(4-fluorophenyl)methanimine) (1648-04-0) → N1,N2-bis(4-fluorobenzyl)ethane-1,2-diamine (1581-26-6)

Guidance literature:

With methanol; sodium tetrahydroborate; at 20 ℃; for 4h; Cooling with ice;

DOI:10.1016/j.bmc.2019.02.051

Reference yield: 78.0%

tetrakis(actonitrile)copper(I) hexafluorophosphate (64443-05-6) + N,N'-(ethane-1,2-diyl)bis(1-(4-fluorophenyl)methanimine) (1648-04-0) → C32H28CuF4N4(1+)*F6P(1-)

Guidance literature:

In dichloromethane; at 25 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1039/c9ob01331h

upstream raw materials:

4-fluorobenzaldehyde

ethylenediamine

Downstream raw materials:

C₂₀H₁₈F₂N₂O₂S₂

N¹-4-fluorobenzylethane-1,3-diamine

1-(4-fluorobenzyl)-4,5-dihydro-2-(4-fluorophenyl)-1H-imidazole

7,10-bis(4-fluorobenzyl)-2,2,4,4-tetrachloro-1,3,5,7,10-pentaaza-2λ5,4λ5,6λ5-triphosphaspiro[4.5]deca-1,3,5-triene