(E)-(3,4-difluorophenyl){5-[(7-pyrazolo[1,5-b]pyridazin-3-yl-2,7-diazaspiro[4.4]non-2-yl)methyl]-2-pyridinyl}methanone O-ethyloxime

Base Information

Chemical Name:(E)-(3,4-difluorophenyl){5-[(7-pyrazolo[1,5-b]pyridazin-3-yl-2,7-diazaspiro[4.4]non-2-yl)methyl]-2-pyridinyl}methanone O-ethyloxime
CAS No.:1202177-91-0
Molecular Formula:C₂₈H₂₉F₂N₇O
Molecular Weight:517.581
Hs Code.:

Synonyms:(E)-(3,4-difluorophenyl){5-[(7-pyrazolo[1,5-b]pyridazin-3-yl-2,7-diazaspiro[4.4]non-2-yl)methyl]-2-pyridinyl}methanone O-ethyloxime

Suppliers and Price of (E)-(3,4-difluorophenyl){5-[(7-pyrazolo[1,5-b]pyridazin-3-yl-2,7-diazaspiro[4.4]non-2-yl)methyl]-2-pyridinyl}methanone O-ethyloxime

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-(3,4-difluorophenyl){5-[(7-pyrazolo[1,5-b]pyridazin-3-yl-2,7-diazaspiro[4.4]non-2-yl)methyl]-2-pyridinyl}methanone O-ethyloxime

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-(3,4-difluorophenyl){5-[(7-pyrazolo[1,5-b]pyridazin-3-yl-2,7-diazaspiro[4.4]non-2-yl)methyl]-2-pyridinyl}methanone O-ethyloxime

There total 6 articles about (E)-(3,4-difluorophenyl){5-[(7-pyrazolo[1,5-b]pyridazin-3-yl-2,7-diazaspiro[4.4]non-2-yl)methyl]-2-pyridinyl}methanone O-ethyloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1137949-68-8
3-bromopyrazolo[1,5-b]pyridazine

: 1202179-20-1
(E)-[5-(2,7-diazaspiro[4.4]non-2-ylmethyl)-2-pyridinyl](3,4-difluorophenyl)methanone O-ethyloxime

: 1202177-91-0
(E)-(3,4-difluorophenyl){5-[(7-pyrazolo[1,5-b]pyridazin-3-yl-2,7-diazaspiro[4.4]non-2-yl)methyl]-2-pyridinyl}methanone O-ethyloxime

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In toluene; for 12h; Reflux; Inert atmosphere;

Reference yield:

: 1017599-32-4
(E)-(3,4-difluorophenyl)[5-(hydroxymethyl)pyridine-2-yl]methanone O-ethyloxime

: 1202177-91-0
(E)-(3,4-difluorophenyl){5-[(7-pyrazolo[1,5-b]pyridazin-3-yl-2,7-diazaspiro[4.4]non-2-yl)methyl]-2-pyridinyl}methanone O-ethyloxime

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / ethyl acetate / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 15 h / 80 °C

3: trifluoroacetic acid / chloroform / 0.5 h / 0 - 20 °C

4: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / toluene / 12 h / Reflux; Inert atmosphere

With triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 2306252-57-1
2,7-diazaspiro[4.4]-nonane-2-carboxylic acid tert-butyl ester

: 1202177-91-0
(E)-(3,4-difluorophenyl){5-[(7-pyrazolo[1,5-b]pyridazin-3-yl-2,7-diazaspiro[4.4]non-2-yl)methyl]-2-pyridinyl}methanone O-ethyloxime

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 15 h / 80 °C

2: trifluoroacetic acid / chloroform / 0.5 h / 0 - 20 °C

3: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / toluene / 12 h / Reflux; Inert atmosphere

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In chloroform; N,N-dimethyl-formamide; toluene;