2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-4a-ethyl-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Base Information

Chemical Name:2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-4a-ethyl-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate
CAS No.:85923-70-2
Molecular Formula:C₂₇H₂₉Cl₃N₂O₅S
Molecular Weight:599.963
Hs Code.:

Synonyms:2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-4a-ethyl-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

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Chemical Property of 2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-4a-ethyl-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

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Technology Process of 2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-4a-ethyl-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

There total 7 articles about 2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-4a-ethyl-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 85923-67-7
(E)-1-<(p-methoxyphenyl)sulfonyl>-2-methyl-3-indole

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 85923-70-2
2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-4a-ethyl-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In chlorobenzene; at 135 ℃; for 10h;
DOI:10.1021/ja00352a037

Reference yield:

: 5416-80-8
2-methyl-1H-indole-3-carbaldehyde

: 85923-70-2
2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-4a-ethyl-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium hydride, 2.) imidazole / 1.) glyme, 20 deg C, 1.5 h, reflux, 15 min, 2.) 20 deg C, 15 h

2: CH₂Cl₂ / 15 h / 4 Angstroem molecular sieves

3: 46 percent / diisopropylethylamine / chlorobenzene / 10 h / 135 °C

With 1H-imidazole; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; chlorobenzene;
DOI:10.1021/ja00352a037

Reference yield:

: 13722-73-1
4-ethylpent-4-enoic acid

: 85923-70-2
2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-4a-ethyl-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) triethylamine, 2.) ethyl chloroformate, 3.) ammonia / 1.) dichloromethane, 0 deg C, 10 min, 2.) 0 deg C, 1 h, 0 deg C -> 20 deg c, 0.5 h, 3.) 20 deg C, 15 h

2: 49 percent / lithium aluminum hydride / diethyl ether / 15 h / 20 °C

3: CH₂Cl₂ / 15 h / 4 Angstroem molecular sieves

4: 46 percent / diisopropylethylamine / chlorobenzene / 10 h / 135 °C

With lithium aluminium tetrahydride; ammonia; chloroformic acid ethyl ester; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; chlorobenzene;
DOI:10.1021/ja00352a037