(R)-4-(4-((2,4-dimethoxybenzyl)amino)-1-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Base Information

Chemical Name:(R)-4-(4-((2,4-dimethoxybenzyl)amino)-1-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide
CAS No.:1620564-54-6
Molecular Formula:C₃₅H₃₂F₃N₉O₃
Molecular Weight:683.693
Hs Code.:

(R)-4-(4-((2,4-dimethoxybenzyl)amino)-1-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Synonyms:(R)-4-(4-((2,4-dimethoxybenzyl)amino)-1-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

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Chemical Property of (R)-4-(4-((2,4-dimethoxybenzyl)amino)-1-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

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Technology Process of (R)-4-(4-((2,4-dimethoxybenzyl)amino)-1-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

There total 13 articles about (R)-4-(4-((2,4-dimethoxybenzyl)amino)-1-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418307-30-8
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-N-(4-trifluoromethyl-pyridin-2-yl)-benzamide

: 1620564-50-2
(R)-3-bromo-N-(2,4-dimethoxybenzyl)-1-(4,5,6,7-tetrahydro-1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 74-88-4
methyl iodide

: 1620564-53-5
(R)-4-(4-((2,4-dimethoxybenzyl)amino)-1-(1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

: 1620564-54-6
(R)-4-(4-((2,4-dimethoxybenzyl)amino)-1-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Guidance literature:: (R)-3-bromo-N-(2,4-dimethoxybenzyl)-1-(4,5,6,7-tetrahydro-1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; methyl iodide; With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 0.25h; Microwave irradiation;

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-N-(4-trifluoromethyl-pyridin-2-yl)-benzamide; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 2h; Overall yield = 72.9 %; Overall yield = 100 mg; Inert atmosphere;

Reference yield:

: 85302-07-4
2-(dimethylaminomethylene)cyclohexane-1,3-dione

: 1620564-53-5
(R)-4-(4-((2,4-dimethoxybenzyl)amino)-1-(1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

: 1620564-54-6
(R)-4-(4-((2,4-dimethoxybenzyl)amino)-1-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / ethanol / 4 h / 70 °C

2.1: sodium tetrahydroborate; ethanol / tetrahydrofuran / 1 h / Cooling with ice

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4.08 h / 0 - 20 °C / Inert atmosphere

4.1: chiralpak AS-H 150*4.6mm I_.D_., 5um / methanol / Resolution of racemate

5.1: lithium hydroxide monohydrate / tetrahydrofuran / 8 h / 60 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 70 °C / Microwave irradiation

6.2: 2 h / 90 °C / Inert atmosphere

With sodium tetrahydroborate; lithium hydroxide monohydrate; ethanol; di-isopropyl azodicarboxylate; caesium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 106447-97-6
2-amino-4-(trifluoromethyl)pyridine

: 1620564-53-5
(R)-4-(4-((2,4-dimethoxybenzyl)amino)-1-(1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

: 1620564-54-6
(R)-4-(4-((2,4-dimethoxybenzyl)amino)-1-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / acetonitrile / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 70 °C / Microwave irradiation

2.2: 2 h / 90 °C / Inert atmosphere

With dmap; caesium carbonate; In N,N-dimethyl-formamide; acetonitrile;