(2R,5S,8S,11S,15S)-8-Benzyl-5-(3-guanidino-propyl)-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaaza-cycloheptadecane-11,15-dicarboxylic acid

Base Information

Chemical Name:(2R,5S,8S,11S,15S)-8-Benzyl-5-(3-guanidino-propyl)-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaaza-cycloheptadecane-11,15-dicarboxylic acid
CAS No.:868840-76-0
Molecular Formula:C₂₇H₃₈N₈O₉
Molecular Weight:618.647
Hs Code.:

Synonyms:(2R,5S,8S,11S,15S)-8-Benzyl-5-(3-guanidino-propyl)-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaaza-cycloheptadecane-11,15-dicarboxylic acid

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Chemical Property of (2R,5S,8S,11S,15S)-8-Benzyl-5-(3-guanidino-propyl)-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaaza-cycloheptadecane-11,15-dicarboxylic acid

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Technology Process of (2R,5S,8S,11S,15S)-8-Benzyl-5-(3-guanidino-propyl)-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaaza-cycloheptadecane-11,15-dicarboxylic acid

There total 5 articles about (2R,5S,8S,11S,15S)-8-Benzyl-5-(3-guanidino-propyl)-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaaza-cycloheptadecane-11,15-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 868840-75-9
C₄₉H₇₂N₈O₁₂S

: 868840-76-0
(2R,5S,8S,11S,15S)-8-Benzyl-5-(3-guanidino-propyl)-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaaza-cycloheptadecane-11,15-dicarboxylic acid

Guidance literature:: With methyl-phenyl-thioether; trifluoroacetic acid; In dichloromethane; for 2h;
DOI:10.1016/j.bmcl.2005.07.068

Reference yield:

: 18342-66-0
2,5-dioxopyrrolidin-1-yl methylcarbamate

: C₃₁H₄₅N₈O₉Pol

: 868840-76-0
(2R,5S,8S,11S,15S)-8-Benzyl-5-(3-guanidino-propyl)-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaaza-cycloheptadecane-11,15-dicarboxylic acid

: 1115069-00-5
C₃₁H₄₄N₁₀O₁₁

: 243975-37-3
cyclo(N^w-(N-methylcarbamoyl)-L-arginyl-N-methyl-L-phenylalanyl-β-L-aspartyl-β-L-aspartyl-D-alanyl)

Guidance literature:: 2,5-dioxopyrrolidin-1-yl methylcarbamate; C₃₁H₄₅N₈O₉Pol; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; for 2h; solid phase reaction;

With trifluoroacetic acid; In dichloromethane; for 0.333333h; solid phase reaction;

With hydrogenchloride; water; at 60 ℃; for 1.5h; solid phase reaction;
DOI:10.1039/b815077j

Reference yield:

: 868840-74-8
C₄₉H₇₄N₈O₁₃S

: 868840-76-0
(2R,5S,8S,11S,15S)-8-Benzyl-5-(3-guanidino-propyl)-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaaza-cycloheptadecane-11,15-dicarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / PyBOP; DIPEA / CH₂Cl₂ / 16 h / pH 8

2: 28 percent / aq. TFA; thioanisole / CH₂Cl₂ / 2 h

With methyl-phenyl-thioether; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2005.07.068