868840-74-8Relevant articles and documents
An efficient synthesis of argifin: A natural product chitinase inhibitor with chemotherapeutic potential
Dixon, Mark J.,Andersen, Ole A.,Van Aalten, Daan M. F.,Eggleston, Ian M.
, p. 4717 - 4721 (2005)
The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.