868840-75-9

Upstream product

• 119831-72-0 Fmoc-Arg(Pbf)-OH 
• 129460-09-9 Fmoc-Asp-O-t-Bu 
• 868840-74-8 C₄₉H₇₄N₈O₁₃S 

Downstream Products

• 868840-76-0 (2R,5S,8S,11S,15S)-8-Benzyl-5-(3-guanidino-propyl)-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaaza-cycloheptadecane-11,15-dicarboxylic acid 
• 243975-37-3 cyclo(N^w-(N-methylcarbamoyl)-L-arginyl-N-methyl-L-phenylalanyl-β-L-aspartyl-β-L-aspartyl-D-alanyl) 

Relevant academic research and scientific papers

An efficient synthesis of argifin: A natural product chitinase inhibitor with chemotherapeutic potential

The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.