243975-37-3

Usage

Uses

Used in Medicinal Applications:
(2R,5S,8S,11S,15S)-5-[3-((E)-amino[(methylcarbamoyl)amino]methylideneamino)propyl]-8-benzyl-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaazacycloheptadecane-11,15-dicarboxylic acid is used as a potential therapeutic agent for various medical conditions due to its complex structure and multiple functional groups that may enable it to bind with proteins or engage in other molecular interactions.
Used in Research Applications:
In the field of scientific research, (2R,5S,8S,11S,15S)-5-[3-({(E)-amino[(methylcarbamoyl)amino]methylidene}amino)propyl]-8-benzyl-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaazacycloheptadecane-11,15-dicarboxylic acid is used as a tool to study molecular interactions, protein binding, and other biological processes. Its unique structure and functional groups make it a valuable asset for understanding complex biological systems and developing new therapeutic strategies.

Upstream product

• 1324007-50-2 C₁₀₇H₁₇₉N₉O₁₆ 
• 18342-66-0 2,5-dioxopyrrolidin-1-yl methylcarbamate 
• 119831-72-0 Fmoc-Arg(Pbf)-OH 
• 129460-09-9 Fmoc-Asp-O-t-Bu 
• 868840-74-8 C₄₉H₇₄N₈O₁₃S 
• 868840-75-9 C₄₉H₇₂N₈O₁₂S 
• 868840-76-0 (2R,5S,8S,11S,15S)-8-Benzyl-5-(3-guanidino-propyl)-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaaza-cycloheptadecane-11,15-dicarboxylic acid 

Relevant academic research and scientific papers

Solution-phase total synthesis of the hydrophilic natural product argifin using 3,4,5-tris(octadecyloxy)benzyl tag

A solution-phase total synthesis of argifin using 3,4,5-tris(octadecyloxy) benzyl tag as a hydrophobic protective group of carboxylic acid was developed to produce 44% overall yield for 16 linear steps. Argifin, a novel class of natural product chitinase

Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold

A new, highly efficient, all-solid-phase synthesis of argifin, a natural product cyclic pentapeptide chitinase inhibitor, is reported. The synthesis features attachment of an orthogonally protected Asp residue to the solid support and assembly of the line

Argifin; efficient solid phase total synthesis and evalution of analogues of acyclic peptide

An effective solid phase synthesis of Argifin, providing subsequent access to effective synthesis of analogues, was developed in 13% overall yield, as well as elucidating structure-activity relationships. The novel acyclic peptide 18b, prepared from a synthetic intermediate of Argifin, was found to be 70 times more potent as an inhibitor of Serratia marcescens chitinases B than Argifin itself.

An efficient synthesis of argifin: A natural product chitinase inhibitor with chemotherapeutic potential

The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.