N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine allyl ester

Base Information

Chemical Name:N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine allyl ester
CAS No.:236424-95-6
Molecular Formula:C₄₆H₇₅N₅O₉S
Molecular Weight:874.196
Hs Code.:

Synonyms:N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine allyl ester

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Chemical Property of N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine allyl ester

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Technology Process of N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine allyl ester

There total 5 articles about N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 207398-66-1
N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteine

: L-phenylalanyl-glycyl-L-leucine allyl ester hydrotrifluoroacetate

: 236424-95-6
N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine allyl ester

Guidance literature:: With benzotriazol-1-ol; dacarbazine; triethylamine; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1016/S0968-0896(98)00251-X

Reference yield:

: 4530-20-5
BOC-glycine

: 236424-95-6
N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / DIC, HOBt, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

2: 1.) DTT, Et₃N, 2.) Et₃N / 1.) CH₂Cl₂, rt, 2 h, 2.) CH₂Cl₂, rt, 2 h

3: 89 percent / Pd(PPh₃)4, morpholine / tetrahydrofuran / 1 h / Ambient temperature

4: 78 percent / DIC, HOBt, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; DL-dithiothreitol; benzotriazol-1-ol; dacarbazine; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0968-0896(98)00251-X

Reference yield:

: 207398-65-0
N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteine allyl ester

: 236424-95-6
N-tert-butyloxycarbonyl-glycyl-(S-palmitoyl)-L-cysteyl-L-phenylalanyl-glycine-L-leucine allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / Pd(PPh₃)4, morpholine / tetrahydrofuran / 1 h / Ambient temperature

2: 78 percent / DIC, HOBt, Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-ol; dacarbazine; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0968-0896(98)00251-X