5-amino-6-cyano-2-(4-methoxy-benzylidene)-3-oxo-7-p-tolyl-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-8-carboxylic acid amide

Base Information

• Chemical Name: 5-amino-6-cyano-2-(4-methoxy-benzylidene)-3-oxo-7-p-tolyl-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-8-carboxylic acid amide
• CAS No.: 879197-27-0
• Molecular Formula: C₂₄H₂₀N₄O₃S
• Molecular Weight: 444.514

Synonyms:5-amino-6-cyano-2-(4-methoxy-benzylidene)-3-oxo-7-p-tolyl-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-8-carboxylic acid amide

Chemical Property of 5-amino-6-cyano-2-(4-methoxy-benzylidene)-3-oxo-7-p-tolyl-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-8-carboxylic acid amide

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Technology Process of 5-amino-6-cyano-2-(4-methoxy-benzylidene)-3-oxo-7-p-tolyl-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-8-carboxylic acid amide

There total 4 articles about 5-amino-6-cyano-2-(4-methoxy-benzylidene)-3-oxo-7-p-tolyl-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-8-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-{5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-4-oxo-4,5-dihydro-thiazol-2-yl}-acetamide (879197-08-7) + 2-(4-methylbenzylidene)malononitrile (2826-25-7) → 5-amino-6-cyano-2-(4-methoxy-benzylidene)-3-oxo-7-p-tolyl-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-8-carboxylic acid amide (879197-27-0)

Guidance literature:

With piperidine; In ethanol; for 6h; Heating;

DOI:10.1080/104265090889620

Reference yield:

4-Oxo-4,5-dihydro-1,3-thiazole-2-acetamide (87947-93-1) → 5-amino-6-cyano-2-(4-methoxy-benzylidene)-3-oxo-7-p-tolyl-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-8-carboxylic acid amide (879197-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / piperidine / ethanol / 3 h / Heating

2: 87 percent / piperidine / ethanol / 6 h / Heating

With piperidine; In ethanol;

DOI:10.1080/104265090889620

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 5-amino-6-cyano-2-(4-methoxy-benzylidene)-3-oxo-7-p-tolyl-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-8-carboxylic acid amide (879197-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / piperidine / ethanol / 3 h / Heating

2: 87 percent / piperidine / ethanol / 6 h / Heating

With piperidine; In ethanol;

DOI:10.1080/104265090889620

upstream raw materials:

2-{5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-4-oxo-4,5-dihydro-thiazol-2-yl}-acetamide

2-(4-methylbenzylidene)malononitrile

4-methyl-benzaldehyde

malononitrile

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