(1H-benzimidazol-2-yl)-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)amine

Base Information

Chemical Name:(1H-benzimidazol-2-yl)-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)amine
CAS No.:104472-63-1
Molecular Formula:C₂₁H₂₆N₄O
Molecular Weight:350.464
Hs Code.:

Synonyms:(1H-benzimidazol-2-yl)-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)amine

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Chemical Property of (1H-benzimidazol-2-yl)-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)amine

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Technology Process of (1H-benzimidazol-2-yl)-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)amine

There total 10 articles about (1H-benzimidazol-2-yl)-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 4857-06-1
2-chloro-1H-benzoimidazole

: 85098-70-0
4-amino-1-(2-(4-methoxyphenyl)ethyl)piperidine

: 104472-63-1
(1H-benzimidazol-2-yl)-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)amine

Guidance literature:: In neat (no solvent); at 120 ℃; for 16h; Schlenk technique; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.joc.1c01467

Reference yield: 56.0%

: 124794-72-5
1-(2-aminophenyl)-3-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)thiourea

: 104472-63-1
(1H-benzimidazol-2-yl)-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)amine

Guidance literature:: With sulfur; mercury(II) oxide; In ethanol; for 10h; Reflux;
DOI:10.1002/cmdc.201300172

Reference yield:

: 85098-70-0
4-amino-1-(2-(4-methoxyphenyl)ethyl)piperidine

: 104472-63-1
(1H-benzimidazol-2-yl)-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)amine

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 25 °C

2: H₂, NH₃ / 10 percent Pd/C / methanol / 760 Torr / Ambient temperature

3: yellow HgO, sulfur / ethanol / 2 h / Heating

With ammonia; hydrogen; sulfur; mercury(II) oxide; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1021/jm00150a029