(S)-4-tert-butyl-2-(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-4,5-dihydrooxazole

Base Information

Chemical Name:(S)-4-tert-butyl-2-(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-4,5-dihydrooxazole
CAS No.:1092491-37-6
Molecular Formula:C₂₉H₂₂F₁₂NOP
Molecular Weight:659.454
Hs Code.:

Synonyms:(S)-4-tert-butyl-2-(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-4,5-dihydrooxazole

Suppliers and Price of (S)-4-tert-butyl-2-(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-4,5-dihydrooxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-tert-butyl-2-(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-4,5-dihydrooxazole

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (S)-4-tert-butyl-2-(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-4,5-dihydrooxazole

There total 1 articles about (S)-4-tert-butyl-2-(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.5%

: 154701-60-7
2-(2-bromophenyl)-4-(1,1-dimethylethyl)-4,5-dihydro-(4S)-oxazole

: 142421-57-6
bis(3,5-di(trifluoromethyl)phenyl)chlorophosphine

: 1092491-37-6
(S)-4-tert-butyl-2-(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-4,5-dihydrooxazole

Guidance literature:: 2-(2-bromophenyl)-4-(1,1-dimethylethyl)-4,5-dihydro-(4S)-oxazole; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 1h; Inert atmosphere;

bis(3,5-di(trifluoromethyl)phenyl)chlorophosphine; In diethyl ether; pentane; at -78 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jacs.7b03480

Reference yield: 100.0%

: 14104-20-2
silver tetrafluoroborate

: bis(η3-allyl-μ-chloropalladium(II))

: 1092491-37-6
(S)-4-tert-butyl-2-(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-4,5-dihydrooxazole

: C₃₂H₂₇F₁₂NOPPd⁽¹⁺⁾*BF₄^(1-)

Guidance literature:: bis(η3-allyl-μ-chloropalladium(II)); (S)-4-tert-butyl-2-(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-4,5-dihydrooxazole; In dichloromethane; at 20 ℃; for 0.333333h; Inert atmosphere;

silver tetrafluoroborate; In dichloromethane; at 22 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1021/jacs.7b13300

Reference yield: 92.5%

: bis(η3-allyl-μ-chloropalladium(II))

: 1092491-37-6
(S)-4-tert-butyl-2-(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-4,5-dihydrooxazole

: 79060-88-1
sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate

: C₃₂H₂₇F₁₂NOPPd⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-)

Guidance literature:: bis(η3-allyl-μ-chloropalladium(II)); (S)-4-tert-butyl-2-(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-4,5-dihydrooxazole; In dichloromethane; at 20 ℃; for 0.5h; Sealed tube;

sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In dichloromethane; for 1h; Sealed tube;
DOI:10.1021/acs.orglett.0c00412