(S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5,7-dimethoxycoumarin

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Chemical Name:(S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5,7-dimethoxycoumarin
CAS No.:1560773-66-1
Molecular Formula:C₃₃H₃₆N₂O₉
Molecular Weight:604.657
Hs Code.:

Synonyms:(S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5,7-dimethoxycoumarin

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Chemical Property of (S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5,7-dimethoxycoumarin

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Technology Process of (S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5,7-dimethoxycoumarin

There total 9 articles about (S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5,7-dimethoxycoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1560773-55-8
4-(3-amino-4-methoxyphenyl)-5,7-dimethoxycoumarin

: 23680-31-1
BOC-O-benzyl-L-serine

: 1560773-66-1
(S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5,7-dimethoxycoumarin

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 15h; Inert atmosphere;
DOI:10.1007/s11172-013-0149-3

Reference yield:

: 262433-23-8
2-(3-tert-butoxycarbonylamino-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1560773-66-1
(S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5,7-dimethoxycoumarin

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 17 h / 20 - 110 °C / Inert atmosphere

2.1: hydrogenchloride; ethanol / ethyl acetate / 50 °C

2.2: 0.5 h / 20 °C

3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h / 20 - 50 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: |Suzuki-Miyaura Coupling;
DOI:10.1007/s11172-013-0149-3

Reference yield:

: 52692-09-8
4-iodo-2-nitroanisole

: 1560773-66-1
(S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5,7-dimethoxycoumarin

Guidance literature:: Multi-step reaction with 6 steps

1.1: tin(II) chloride hydrate / ethanol; ethyl acetate / 0.5 h / 70 °C

2.1: ethanol / 36 h / 20 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere

4.1: potassium carbonate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 17 h / 20 - 110 °C / Inert atmosphere

5.1: hydrogenchloride; ethanol / ethyl acetate / 50 °C

5.2: 0.5 h / 20 °C

6.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h / 20 - 50 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride hydrate; ethanol; potassium acetate; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1007/s11172-013-0149-3