cis-N-({1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}methyl)methanesulphonamide

Base Information

Chemical Name:cis-N-({1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}methyl)methanesulphonamide
CAS No.:1256569-92-2
Molecular Formula:C₁₉H₂₆F₃N₃O₄S
Molecular Weight:449.494
Hs Code.:

Synonyms:cis-N-({1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}methyl)methanesulphonamide

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Chemical Property of cis-N-({1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}methyl)methanesulphonamide

Chemical Property:

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Technology Process of cis-N-({1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}methyl)methanesulphonamide

There total 10 articles about cis-N-({1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}methyl)methanesulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256570-50-9
{3-(aminomethyl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone

: 124-63-0
methanesulfonyl chloride

: 1256569-92-2
cis-N-({1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}methyl)methanesulphonamide

: 1256569-91-1
cis-N-({1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}methyl)methanesulphonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 118650-08-1
(5-bromo-pyridin-3-yl)-acetic acid methyl ester

: 1256569-92-2
cis-N-({1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}methyl)methanesulphonamide

: 1256569-91-1
cis-N-({1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}methyl)methanesulphonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water; dimethoxyethane-1,2 / 20 - 85 °C / Inert atmosphere

2.1: hydrogen / palladium on activated charcoal / ethanol; water / 60 °C / 37503.8 Torr / Inert atmosphere

3.1: dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: water; lithium hydroxide / tetrahydrofuran / 20 - 60 °C

4.2: pH 1

5.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 0 - 20 °C

5.2: Cooling with ice

6.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

6.2: 1 h / 0 - 20 °C

7.1: sodium azide / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

8.1: hydrogen / palladium on activated charcoal / ethanol; water / 24 h / 20 °C / 760.05 Torr

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With sodium tetrahydroborate; sodium azide; boron trifluoride diethyl etherate; water; hydrogen; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; dimethoxyethane-1,2; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1256570-48-5
1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-methanesulphonate

: 1256569-92-2
cis-N-({1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}methyl)methanesulphonamide

: 1256569-91-1
cis-N-({1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}methyl)methanesulphonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

2: hydrogen / palladium on activated charcoal / ethanol; water / 24 h / 20 °C / 760.05 Torr

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With sodium azide; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;