[(R)-1-((1S,4S)-2-Iodo-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-3-trimethylsilanyl-prop-2-ynyloxy]-benzene

Base Information

• Chemical Name: [(R)-1-((1S,4S)-2-Iodo-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-3-trimethylsilanyl-prop-2-ynyloxy]-benzene
• CAS No.: 791072-91-8
• Molecular Formula: C₂₅H₃₉IO₄Si₂
• Molecular Weight: 586.658
• Mol file: 791072-91-8.mol

Synonyms:[(R)-1-((1S,4S)-2-Iodo-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-3-trimethylsilanyl-prop-2-ynyloxy]-benzene

Chemical Property of [(R)-1-((1S,4S)-2-Iodo-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-3-trimethylsilanyl-prop-2-ynyloxy]-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(R)-1-((1S,4S)-2-Iodo-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-3-trimethylsilanyl-prop-2-ynyloxy]-benzene

There total 4 articles about [(R)-1-((1S,4S)-2-Iodo-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-3-trimethylsilanyl-prop-2-ynyloxy]-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-trimethyl-silane (75-77-4) + Triethyl-[(1S,4S)-2-iodo-4-methoxymethoxy-1-((R)-1-phenoxy-prop-2-ynyl)-cyclopent-2-enyloxy]-silane → [(R)-1-((1S,4S)-2-Iodo-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-3-trimethylsilanyl-prop-2-ynyloxy]-benzene (791072-91-8)

Guidance literature:

With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

DOI:10.1021/ol048494i

Reference yield:

triethylsilyl chloride (994-30-9) → [(R)-1-((1S,4S)-2-Iodo-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-3-trimethylsilanyl-prop-2-ynyloxy]-benzene (791072-91-8)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 1.17 h / 50 °C

2: 1.45 g / HN(TMS)2; n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

With 1H-imidazole; n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1021/ol048494i

Reference yield:

(2S,3S,6S)-2-Ethynyl-4-iodo-6-methoxymethoxy-1-oxa-spiro[2.4]hept-4-ene (791072-89-4) → [(R)-1-((1S,4S)-2-Iodo-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-3-trimethylsilanyl-prop-2-ynyloxy]-benzene (791072-91-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / CsF / dimethylformamide / 4 h / 80 °C

2: imidazole / dimethylformamide / 1.17 h / 50 °C

3: 1.45 g / HN(TMS)2; n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

With 1H-imidazole; n-butyllithium; cesium fluoride; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1021/ol048494i

upstream raw materials:

chloro-trimethyl-silane

triethylsilyl chloride

(2S,3S,6S)-2-Ethynyl-4-iodo-6-methoxymethoxy-1-oxa-spiro[2.4]hept-4-ene

(1S,4S)-2-Iodo-4-methoxymethoxy-1-((R)-1-phenoxy-prop-2-ynyl)-cyclopent-2-enol

Downstream raw materials:

2,2-Dimethyl-propionic acid (2S,3S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(4-methoxy-benzyloxy)-5-[(3S,5R)-3-methoxymethoxy-5-((R)-1-phenoxy-prop-2-ynyl)-5-triethylsilanyloxy-cyclopent-1-enyl]-3-triethylsilanyloxy-pent-4-ynyl ester

C₄₈H₇₀O₁₂SSi₂

C₄₆H₆₆O₁₁SSi₂

2,2-Dimethyl-propionic acid (2S,3S)-3-hydroxymethyl-2-(4-methoxy-benzyloxy)-5-[(3S,5R)-3-methoxymethoxy-5-((R)-1-phenoxy-prop-2-ynyl)-5-triethylsilanyloxy-cyclopent-1-enyl]-3-triethylsilanyloxy-pent-4-ynyl ester