28-oxy trimethylsilyl-43-0-(4-nitrophenoxycarbonyl)oxy rapamycin

Base Information

Chemical Name:28-oxy trimethylsilyl-43-0-(4-nitrophenoxycarbonyl)oxy rapamycin
CAS No.:1192721-95-1
Molecular Formula:C₆₁H₉₀N₂O₁₇Si
Molecular Weight:1151.47
Hs Code.:

Synonyms:28-oxy trimethylsilyl-43-0-(4-nitrophenoxycarbonyl)oxy rapamycin

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Chemical Property of 28-oxy trimethylsilyl-43-0-(4-nitrophenoxycarbonyl)oxy rapamycin

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Technology Process of 28-oxy trimethylsilyl-43-0-(4-nitrophenoxycarbonyl)oxy rapamycin

There total 2 articles about 28-oxy trimethylsilyl-43-0-(4-nitrophenoxycarbonyl)oxy rapamycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 331810-10-7
31-(trimethylsilylether)rapamycin

: 7693-46-1
4-Nitrophenyl chloroformate

: 1192721-95-1
28-oxy trimethylsilyl-43-0-(4-nitrophenoxycarbonyl)oxy rapamycin

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 5 ℃; for 4h;

Reference yield:

: 53123-88-9
sirolimus

: 1192721-95-1
28-oxy trimethylsilyl-43-0-(4-nitrophenoxycarbonyl)oxy rapamycin

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / ethyl acetate / 2 h / 0 - 5 °C

2: triethylamine / dichloromethane / 4 h / 0 - 5 °C

With 1H-imidazole; triethylamine; In dichloromethane; ethyl acetate;