1-(2-fluoro-5-methoxybenzyl)-4-ethoxycarbonyl-6,7-dimethoxyisoquinoline

Base Information

Chemical Name:1-(2-fluoro-5-methoxybenzyl)-4-ethoxycarbonyl-6,7-dimethoxyisoquinoline
CAS No.:798563-51-6
Molecular Formula:C₂₂H₂₂FNO₅
Molecular Weight:399.419
Hs Code.:

Synonyms:1-(2-fluoro-5-methoxybenzyl)-4-ethoxycarbonyl-6,7-dimethoxyisoquinoline

Suppliers and Price of 1-(2-fluoro-5-methoxybenzyl)-4-ethoxycarbonyl-6,7-dimethoxyisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(2-fluoro-5-methoxybenzyl)-4-ethoxycarbonyl-6,7-dimethoxyisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(2-fluoro-5-methoxybenzyl)-4-ethoxycarbonyl-6,7-dimethoxyisoquinoline

There total 8 articles about 1-(2-fluoro-5-methoxybenzyl)-4-ethoxycarbonyl-6,7-dimethoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344688-82-9
C₂₂H₂₄FNO₅

: 798563-51-6
1-(2-fluoro-5-methoxybenzyl)-4-ethoxycarbonyl-6,7-dimethoxyisoquinoline

Guidance literature:: With sulfur; at 165 ℃; neat (no solvent);
DOI:10.1016/j.bmcl.2011.09.009

Reference yield:

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 798563-51-6
1-(2-fluoro-5-methoxybenzyl)-4-ethoxycarbonyl-6,7-dimethoxyisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium / ethanol; toluene

1.2: 80 °C

2.1: hydrogenchloride; palladium on activated charcoal; hydrogen / ethanol / 2585.81 Torr

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane

4.1: phosphorus pentachloride / dichloromethane

5.1: sulfur / 165 °C / neat (no solvent)

With hydrogenchloride; phosphorus pentachloride; palladium on activated charcoal; hydrogen; sodium; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sulfur; triethylamine; In ethanol; dichloromethane; toluene; 4.1: Bischler-Napieralski reaction;
DOI:10.1016/j.bmcl.2011.09.009

Reference yield:

: 36848-69-8
ethyl 2-cyano-2-(3,4-dimethoxyphenyl)acetate

: 798563-51-6
1-(2-fluoro-5-methoxybenzyl)-4-ethoxycarbonyl-6,7-dimethoxyisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; palladium on activated charcoal; hydrogen / ethanol / 2585.81 Torr

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane

3: phosphorus pentachloride / dichloromethane

4: sulfur / 165 °C / neat (no solvent)

With hydrogenchloride; phosphorus pentachloride; palladium on activated charcoal; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sulfur; triethylamine; In ethanol; dichloromethane; 3: Bischler-Napieralski reaction;
DOI:10.1016/j.bmcl.2011.09.009