ethyl 1-(3-(2-(benzyloxy)propan-2-yl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(hydroxy)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate

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Chemical Name:ethyl 1-(3-(2-(benzyloxy)propan-2-yl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(hydroxy)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate
CAS No.:1561965-15-8
Molecular Formula:C₃₆H₄₇NO₄
Molecular Weight:557.773
Hs Code.:

Synonyms:ethyl 1-(3-(2-(benzyloxy)propan-2-yl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(hydroxy)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate

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Chemical Property of ethyl 1-(3-(2-(benzyloxy)propan-2-yl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(hydroxy)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 1-(3-(2-(benzyloxy)propan-2-yl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(hydroxy)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate

There total 8 articles about ethyl 1-(3-(2-(benzyloxy)propan-2-yl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(hydroxy)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1561965-14-7
C₃₀H₃₅NO₄

: 931-50-0
cyclohexylmagnesium bromide

: 1561965-15-8
ethyl 1-(3-(2-(benzyloxy)propan-2-yl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(hydroxy)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 1561965-11-4
1-(2-(benzyloxy)propan-2-yl)-3-bromo-5-(1-methylcyclopropyl)benzene

: 1561965-15-8
ethyl 1-(3-(2-(benzyloxy)propan-2-yl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(hydroxy)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / toluene / Inert atmosphere; Reflux

2: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With potassium phosphate; copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; In tetrahydrofuran; toluene;

Reference yield:

: 618-58-6
3,5-dibromobenzoic acid

: 1561965-15-8
ethyl 1-(3-(2-(benzyloxy)propan-2-yl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(hydroxy)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 2 h / Reflux

1.2: 0 - 20 °C

2.1: tetrahydrofuran; diethyl ether / 0 - 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / -40 °C

3.2: -40 - 20 °C

4.1: palladium diacetate / tetrahydrofuran; diethyl ether / 0 - 20 °C

5.1: n-butyllithium / tetrahydrofuran / -78 °C

5.2: -78 - 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

7.1: potassium phosphate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / toluene / Inert atmosphere; Reflux

8.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With potassium phosphate; copper(l) iodide; n-butyllithium; thionyl chloride; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; palladium diacetate; sodium hydride; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; toluene; mineral oil;