N-((4aS,5S,7aS)-7a-(5-amino-2-fluoro-phenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

Base Information

Chemical Name:N-((4aS,5S,7aS)-7a-(5-amino-2-fluoro-phenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine
CAS No.:1388149-68-5
Molecular Formula:C₁₃H₁₃F₄N₃OS
Molecular Weight:335.325
Hs Code.:

Synonyms:N-((4aS,5S,7aS)-7a-(5-amino-2-fluoro-phenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

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Chemical Property of N-((4aS,5S,7aS)-7a-(5-amino-2-fluoro-phenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

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Technology Process of N-((4aS,5S,7aS)-7a-(5-amino-2-fluoro-phenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

There total 21 articles about N-((4aS,5S,7aS)-7a-(5-amino-2-fluoro-phenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.5%

: 1388149-67-4
N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine hydrochloride

: 1388149-68-5
N-((4aS,5S,7aS)-7a-(5-amino-2-fluoro-phenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

Guidance literature:: N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine hydrochloride; With hydrogenchloride; iron; ammonium chloride; In ethanol; at 20 - 68 ℃; for 3.5h; Inert atmosphere;

With sodium hydroxide; In water; at 20 - 35 ℃; for 1h;

Reference yield:

: (4aS,5S,7aS)-7a-(5-amino-2-fluorophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine

: 1388149-68-5
N-((4aS,5S,7aS)-7a-(5-amino-2-fluoro-phenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

Guidance literature:: With sodium hydroxide; In water; at 20 - 35 ℃;

Reference yield:

: 1262799-42-7
((2S,3R,4S)-4-amino-4-(2-fluorophenyl)-2-(trifluoromethyl)tetrahydrofuran-3-yl)methanol

: 1388149-68-5
N-((4aS,5S,7aS)-7a-(5-amino-2-fluoro-phenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane / 18 h / 20 °C

2.1: trifluoromethylsulfonic anhydride; pyridine / -20 - 0 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; methanol / 16 h / Reflux

4.1: nitric acid; trifluoroacetic acid; sulfuric acid / 0 - 20 °C

4.2: 5 - 21 °C

4.3: 35 - 40 °C

5.1: hydrogenchloride; ammonium chloride; iron / ethanol; water / 20 - 68 °C / Inert atmosphere

6.1: sodium hydroxide / water / 20 - 35 °C

With pyridine; hydrogenchloride; methanol; trifluoromethylsulfonic anhydride; sulfuric acid; nitric acid; iron; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; water;