N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine hydrochloride

Base Information

Chemical Name:N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine hydrochloride
CAS No.:1388149-67-4
Molecular Formula:C₁₃H₁₁F₄N₃O₃S*ClH
Molecular Weight:401.769
Hs Code.:

Synonyms:N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine hydrochloride

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Chemical Property of N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine hydrochloride

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Technology Process of N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine hydrochloride

There total 19 articles about N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.3%

: 1388149-66-3
N-((4aS,5S,7aS)-7a-(2-fluorophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

: 1388149-67-4
N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine hydrochloride

Guidance literature:: N-((4aS,5S,7aS)-7a-(2-fluorophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine; With sulfuric acid; nitric acid; trifluoroacetic acid; at 0 - 20 ℃;

With sodium hydroxide; In water; at 5 - 21 ℃;

With hydrogenchloride; In ethanol; water; at 35 - 40 ℃;

Reference yield:

: 1388149-22-1
N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

: 1388149-67-4
N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; water; at 35 - 40 ℃;

Reference yield:

: 1262799-42-7
((2S,3R,4S)-4-amino-4-(2-fluorophenyl)-2-(trifluoromethyl)tetrahydrofuran-3-yl)methanol

: 1388149-67-4
N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 18 h / 20 °C

2.1: trifluoromethylsulfonic anhydride; pyridine / -20 - 0 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; methanol / 16 h / Reflux

4.1: nitric acid; trifluoroacetic acid; sulfuric acid / 0 - 20 °C

4.2: 5 - 21 °C

4.3: 35 - 40 °C

With pyridine; methanol; trifluoromethylsulfonic anhydride; sulfuric acid; nitric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In dichloromethane;