[[2-bromo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxyphenyl]methoxy](1,1-dimethylethyl)diphenylsilane

Base Information

Chemical Name:[[2-bromo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxyphenyl]methoxy](1,1-dimethylethyl)diphenylsilane
CAS No.:347840-66-8
Molecular Formula:C₃₀H₄₁BrO₃Si₂
Molecular Weight:585.729
Hs Code.:

Synonyms:[[2-bromo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxyphenyl]methoxy](1,1-dimethylethyl)diphenylsilane

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Chemical Property of [[2-bromo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxyphenyl]methoxy](1,1-dimethylethyl)diphenylsilane

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Technology Process of [[2-bromo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxyphenyl]methoxy](1,1-dimethylethyl)diphenylsilane

There total 6 articles about [[2-bromo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxyphenyl]methoxy](1,1-dimethylethyl)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 347840-65-7
2-bromo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxybenzene-methanol

: 347840-66-8
[[2-bromo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxyphenyl]methoxy](1,1-dimethylethyl)diphenylsilane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/ol0159367 DOI:10.1021/ja021396c

Reference yield:

: 1194-98-5
2,5-Dihydroxybenzaldehyde

: 347840-66-8
[[2-bromo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxyphenyl]methoxy](1,1-dimethylethyl)diphenylsilane

Guidance literature:: Multi-step reaction with 5 steps

1.1: Br₂ / CHCl₃ / 20 °C

2.1: 10.64 g / imidazole / CH₂Cl₂ / 0.25 h / 20 °C

3.1: NaH / tetrahydrofuran / 0.5 h

3.2: 72 percent / DMA / tetrahydrofuran / 6 h / 65 °C

4.1: 100 percent / NaBH₄ / ethanol / 0.5 h / 0 °C

5.1: 93 percent / imidazole / dimethylformamide / 2 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; bromine; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ja021396c

Reference yield:

: 241127-72-0
2-bromo-3,6-dihydroxy-benzaldehyde

: 347840-66-8
[[2-bromo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxyphenyl]methoxy](1,1-dimethylethyl)diphenylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 10.64 g / imidazole / CH₂Cl₂ / 0.25 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.5 h

2.2: 72 percent / DMA / tetrahydrofuran / 6 h / 65 °C

3.1: 100 percent / NaBH₄ / ethanol / 0.5 h / 0 °C

4.1: 93 percent / imidazole / dimethylformamide / 2 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja021396c