ethyl 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]glyoxylate

Base Information

• Chemical Name: ethyl 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]glyoxylate
• CAS No.: 945619-98-7
• Molecular Formula: C₂₀H₁₈ClNO₅
• Molecular Weight: 387.82
• Mol file: 945619-98-7.mol

Synonyms:ethyl 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]glyoxylate

Chemical Property of ethyl 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]glyoxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]glyoxylate

There total 1 articles about ethyl 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]glyoxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

oxalyl dichloride (79-37-8) + ethanol (64-17-5) + 3-(4-chlorophenyl)-4,6-dimethoxy-1H-indole (151290-21-0) → ethyl 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]glyoxylate (945619-98-7) + ethyl 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-7-yl]glyoxylate

Guidance literature:

oxalyl dichloride; 3-(4-chlorophenyl)-4,6-dimethoxy-1H-indole; In diethyl ether;

ethanol; at 20 ℃; for 2h;

ethanol; for 2h; Further stages.; Heating;

DOI:10.1016/j.tet.2007.04.087

Reference yield: 82.0%

ethyl 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]glyoxylate (945619-98-7) → ethyl 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]-2-(hydroxyimino)acetate (945620-02-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; for 7h; Heating;

DOI:10.1016/j.tet.2007.04.087

Reference yield:

ethyl 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]glyoxylate (945619-98-7) → ethyl 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]-2-(O-2,4-dinitrophenyloxyimino)acetate (945620-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / hydroxylamine hydrochloride; sodium acetate / ethanol / 7 h / Heating

2: 89 percent / sodium / ethanol / cooling

With hydroxylamine hydrochloride; sodium acetate; sodium; In ethanol;

DOI:10.1016/j.tet.2007.04.087

upstream raw materials:

oxalyl dichloride

ethanol

3-(4-chlorophenyl)-4,6-dimethoxy-1H-indole

Downstream raw materials:

ethyl 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]-2-(hydroxyimino)acetate

ethyl 2-[3-(4-chlorophenyl)-4,6-dimethoxyindol-2-yl]-2-(O-2,4-dinitrophenyloxyimino)acetate