Technology Process of 2',4',6'-trihydroxy-(2,4,5-trimethoxyphenyl)acetophenone
There total 3 articles about 2',4',6'-trihydroxy-(2,4,5-trimethoxyphenyl)acetophenone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3,5-dihydroxyphenol; 2,4,5-trimethoxybenzeneacetonitrile;
With
hydrogenchloride; zinc(II) chloride;
In
diethyl ether;
at 0 - 20 ℃;
for 36h;
Cooling with ice;
With
water;
In
diethyl ether;
for 3h;
Reflux;
DOI:10.1002/ejoc.201201339
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetra-(n-butyl)ammonium iodide / dichloromethane; water / 1.5 h / 20 °C
2.1: hydrogen; palladium 10% on activated carbon / methanol / 72 h / 20 °C / 2660.18 Torr
3.1: zinc(II) chloride; hydrogenchloride / diethyl ether / 36 h / 0 - 20 °C / Cooling with ice
3.2: 3 h / Reflux
With
hydrogenchloride; palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; zinc(II) chloride;
In
methanol; diethyl ether; dichloromethane; water;
3.1: |Houben-Hoesch Phenol Acylation / 3.2: |Houben-Hoesch Phenol Acylation;
DOI:10.1002/ejoc.201201339
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen; palladium 10% on activated carbon / methanol / 72 h / 20 °C / 2660.18 Torr
2.1: zinc(II) chloride; hydrogenchloride / diethyl ether / 36 h / 0 - 20 °C / Cooling with ice
2.2: 3 h / Reflux
With
hydrogenchloride; palladium 10% on activated carbon; hydrogen; zinc(II) chloride;
In
methanol; diethyl ether;
2.1: |Houben-Hoesch Phenol Acylation / 2.2: |Houben-Hoesch Phenol Acylation;
DOI:10.1002/ejoc.201201339
