(S)-N-(3-{3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide

Base Information

Chemical Name:(S)-N-(3-{3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide
CAS No.:1188400-54-5
Molecular Formula:C₁₉H₂₅F₂N₄O₆P
Molecular Weight:474.401
Hs Code.:

Synonyms:(S)-N-(3-{3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide

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Chemical Property of (S)-N-(3-{3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide

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Technology Process of (S)-N-(3-{3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide

There total 9 articles about (S)-N-(3-{3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1188400-85-2
(R)-5-azidomethyl-3-{3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenyl}-oxazolidin-2-one

: 507-09-5
tiolacetic acid

: 1188400-54-5
(S)-N-(3-{3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide

Guidance literature:: at 20 ℃; for 12h;

Reference yield:

: 864072-82-2
1-(2,6-difluoro-4-nitro-phenyl)-piperazine

: 1188400-54-5
(S)-N-(3-{3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: trichlorophosphate / dichloromethane / -78 - 0 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C / Inert atmosphere

2.2: 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / Inert atmosphere

4.1: sodium hydrogencarbonate / water; acetone; toluene / 0 - 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

5.2: 2.08 h / -78 - 20 °C

6.1: triethylamine / dichloromethane / 0 - 20 °C

7.1: sodium azide / N,N-dimethyl-formamide / 80 °C

8.1: 12 h / 20 °C

With n-butyllithium; sodium azide; hydrogen; sodium hydrogencarbonate; triethylamine; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 66684-58-0
3,4,5-trifluoronitrobenzene

: 1188400-54-5
(S)-N-(3-{3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetonitrile / 60 °C

2.1: trichlorophosphate / dichloromethane / -78 - 0 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C / Inert atmosphere

3.2: 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / Inert atmosphere

5.1: sodium hydrogencarbonate / water; acetone; toluene / 0 - 20 °C

6.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

6.2: 2.08 h / -78 - 20 °C

7.1: triethylamine / dichloromethane / 0 - 20 °C

8.1: sodium azide / N,N-dimethyl-formamide / 80 °C

9.1: 12 h / 20 °C

With n-butyllithium; sodium azide; hydrogen; sodium hydrogencarbonate; triethylamine; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;